Wu J.JIH-LUH TANGSHANG-JU WULio H.-Y.YA-CHIEN YANG2020-06-192020-06-1920090009-8981https://scholars.lib.ntu.edu.tw/handle/123456789/503687Background: T cells play a critical role in alloimmune recognition and thus contribute to graft-versus-host disease (GVHD) and relapse prevention in hematopoietic stem cell transplantation (HSCT). Cytotoxic T lymphocyte antigen-4 (CTLA-4) and inducible costimulator (ICOS) are costimulatory molecules of T cell activation and their genetic variations can affect the capacity of T cells to become activated or inactivated. Methods: We examined CTLA-4 (- 318 C/T and + 49 A/G) and ICOS (c.602 A/C and c.1624 C/T) genotypes in 123 patients with HSCT and their HLA-matched sibling donors, and then evaluated the impacts of the genetic polymorphisms on GVHD, disease relapse, and survival. Results: By multivariate analysis, the donor CTLA-4 - 318 TT genotype increased the risk of disease relapse (Hazard ratio [HR]: 5.91, 95% confidence interval [CI]: 1.17-29.79, P = 0.0313). Recipients who received a graft from a donor with ICOS c.602 CC genotype had worse disease-free survival (HR: 5.97, 95% CI: 1.49-23.87, P = 0.0115). Additionally, recipients with ICOS c.1624 TT genotype had worse overall survival (HR: 12.98, 95% CI: 2.58-65.35, P = 0.0019). Nevertheless, CTLA-4 and ICOS genotypes were not associated with acute and chronic GVHD. Conclusions: Both donor and recipient CTLA-4 and ICOS gene polymorphisms might be of importance for the outcome of allogeneic HSCT. ? 2009 Elsevier B.V. All rights reserved.[SDGs]SDG3cytotoxic T lymphocyte antigen 4; adolescent; adult; allogeneic stem cell transplantation; article; child; controlled study; disease free survival; DNA polymorphism; female; gene; gene frequency; genetic association; graft versus host reaction; human; icos gene; major clinical study; male; preschool child; priority journal; relapse; school child; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Female; Genotype; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Male; Multivariate Analysis; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Recurrence; Risk Factors; Siblings; Survival Rate; Transplantation, Homologous; Treatment Outcomejournal article10.1016/j.cca.2009.03.037193320442-s2.0-64849108573