Chen C.-S.CHAO-YUAN HUANGHuang S.-P.Lin V.C.Yu C.-C.Chang T.-Y.Bao B.-Y.2021-10-142021-10-1420151449-1907https://www.scopus.com/inward/record.uri?eid=2-s2.0-84922994270&doi=10.7150%2fijms.10953&partnerID=40&md5=ef7b5c551827c75699e34468ec67f34bhttps://scholars.lib.ntu.edu.tw/handle/123456789/584539Backgroud: Accumulated evidence has demonstrated a significant role of the Wnt pathway in human prostate cancer. We hypothesize that genetic variants in the Wnt pathway effector, Transcription factor 7-like 2 (TCF7L2), may influence clinical outcomes in prostate cancer. Methods: We comprehensively selected 12 tagged single-nucleotide polymorphisms (SNPs) to capture majority of common variants across TCF7L2, and genotyped in 458 localized prostate cancer patients treated with radical prostatectomy (RP). Kaplan-Meier analysis, Cox proportional hazard model, and survival tree analyses were performed to identify significant SNPs that correlated with biochemical recurrence (BCR) after surgery. Results: A higher-order SNP-SNP interaction profile consisting of TCF7L2 rs7094463, rs10749127, and rs11196224 was significantly associated with BCR (Ptrend= 0.001). After adjusting for possible confounders, the genetic profile remained significant (Ptrend= 0.007). None of the studied SNPs were individually associated with BCR. Conclusions: Our results support a genetic interaction in the TCF7L2 SNPs as a predictor of disease recurrence after curative RP in localized prostate cancer patients. ? 2015 Ivyspring International Publisher.Biochemical recurrence; Prostate cancer; Radical prostatectomy; Single-nucleotide polymorphism; TCF7L2; Wnt pathway[SDGs]SDG3transcription factor 7 like 2; TCF7L2 protein, human; transcription factor 7 like 2; adult; aged; Article; biochemical recurrence free survival; cancer prognosis; cancer recurrence; gene; gene expression; gene interaction; genetic association; genetic variability; genotype; human; major clinical study; male; prostate cancer; prostatectomy; single nucleotide polymorphism; Taiwanese; TCF7L2 gene; disease free survival; genetics; Kaplan Meier method; middle aged; pathology; prognosis; Prostatic Neoplasms; tumor recurrence; Wnt signaling pathway; Aged; Disease-Free Survival; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Recurrence, Local; Polymorphism, Single Nucleotide; Prognosis; Prostatectomy; Prostatic Neoplasms; Transcription Factor 7-Like 2 Protein; Wnt Signaling Pathwayjournal article10.7150/ijms.10953256788412-s2.0-84922994270