I-CHUN CHENCHIUN HSUChen Y.C.Chien S.F.HSIANG-FONG KAOChang S.Y.Hu F.C.KUN-HUEI YEH2021-01-282021-01-2820130923-7534https://www.scopus.com/inward/record.uri?eid=2-s2.0-84873810896&doi=10.1093%2fannonc%2fmds468&partnerID=40&md5=c1d4f46e654e7352c714b57d1a266ecbhttps://scholars.lib.ntu.edu.tw/handle/123456789/543499Background: The purpose of this study is to characterize the risk factors of bloodstream infection (BSI) associated with the use of permanent implantable venous ports (Port-A) in solid cancer patients. Methods: Solid cancer patients implanted with a Port-A were prospectively observed for the occurrence of Port-A-associated BSI (PABSI), defined as BSI without other identifiable infection foci. A PABSI risk score was developed using the Cox proportional hazards model. Results: A total of 415 patients were registered; 88 PABSI episodes occurred in 58 patients (incidence1.05 per 1000 catheter-days). All but one patient had stage IV cancer. Independent predictors of PABSI occurrence included neutropenia, total parenteral nutrition (TPN), chronic steroid use, invasive procedures, postoperative antibiotics, and preoperative antibiotics. A PABSI risk score with a cut-off value of 0 (sensitivity 88.5%, specificity 64.3%) was defined for stage IV cancer patients as follows: neutropenia, +1.350; TPN, +1.256; chronic steroid use, +1.947; preoperative antibiotics, -0.970; postoperative antibiotics, +0.959; and invasive procedures, +1.098. The median PABSI-free survival was 4.47 months for patients with scores ?0 but not reached for patients with scores <0 (P < 0.0001). Conclusion: The PABSI risk score can assist in identifying high-risk solid cancer patients and may assist in designing future preventive strategies. ? The Author 2012. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved.[SDGs]SDG3adolescent; adult; aged; antibiotic therapy; article; cancer staging; catheter infection; chronic drug administration; drug use; female; human; infection risk; major clinical study; male; neutropenia; patient identification; Port A associated bloodstream infection score; priority journal; prospective study; risk assessment; risk factor; scoring system; solid tumor; total parenteral nutrition; vascular accessjournal article10.1093/annonc/mds468230599592-s2.0-84873810896