JANN-YUAN WANGChou C.-H.LI-NA LEEHsu H.-L.I-SHIOW JANPO-REN HSUEHPAN-CHYR YANGKWEN-TAY LUH2021-05-262021-05-2620071080-6040https://scholars.lib.ntu.edu.tw/handle/123456789/562486We evaluated an enzyme-linked immunospot assay for interferon-γ (T SPOT-TB) for rapid diagnosis of active tuberculosis (TB) in a disease-endemic area. From January to June 2005, patients whose clinical symptoms and radiographic findings were compatible with TB were recruited, and a blood sample was obtained for T SPOT-TB assay within 7 days of microbiologic studies. Sixty-five patients were studied, including 39 (60%) with active TB. Thirty-five (53.8%) patients had underlying medical conditions. Thirty-seven patients had positive cultures for Mycobacterium tuberculosis, and 11 patients had positive cultures for non-tuberculous mycobacteria. The sensitivity, specificity, positive predictive value, and negative predictive value of the T SPOT-TB assay were 87.2%, 88.5%, 91.9%, and 82.1%, respectively. The accuracy of this test in diagnosing active TB is >80%, even in an area with a high incidence of non-tuberculous mycobacterial disease.[SDGs]SDG3BCG vaccine; clarithromycin; ethambutol; gamma interferon; isoniazid; rifampicin; adolescent; adult; aged; article; bacterium culture; blood sampling; child; clinical feature; controlled study; diagnostic accuracy; enzyme linked immunospot assay; female; human; major clinical study; male; microbiological examination; morbidity; Mycobacterium tuberculosis; radiography; sensitivity and specificity; treatment response; tuberculosisjournal article10.3201/eid1304.051195175532692-s2.0-34047108598