2018-11-012024-05-13https://scholars.lib.ntu.edu.tw/handle/123456789/653403摘要：由於科技與經濟的發展導致高齡化社會的產生，人口結構逐漸老化，神經相關疾病之病患也日益增加，對於社會、家屬與病人的內心著實是很大的負擔。然而接至目前為止並無有效的方法可治療神經退化性疾病。因此，本任務型導向計畫的研究目的乃是赴日本國立研究開發法人物質材料研究機構(National Institute for Materials Science, NIMS)有賀克彥教授研究室學習無機奈米碳材的製備與表面圖樣的設計、製備與修飾之方法。在本計畫擬利用各種結構與型態之奈米碳材之導電性發展成為具有突破創新式之醫療器材產品。由於本團隊發展專長為發展親水性高分子生醫材料，此高分子材料具有良好的親水性但不溶於水，具有好的生物相容性，長期移植至動物體內可被生物體吸收代謝，並可透過成分比例的不同進而調整材料硬度與降解速率，符合移植組織之生理特性，因此於本計畫，我們擬將此優異的親水性高分子材料與奈米碳材結合，期望發展出符合人體組織生理特性之軟電子複合性基材。我們將評估此軟電子複合性基材外來物免疫反應與神經修復力，並根據電性安全與電磁相容標準進行材料最優化。材料最優化後，我們將利用該基材進行修復神經系統醫療器材製備，並將該器材進行以動物模式評估其修復受損神經之能力。計畫結束後，本團隊將會把技術帶回台灣，並與日本團隊共同進行專利申請、臨床試驗規劃與市場調查，為量產上市做預備。 Abstract: With the rapid development of technology and economy, the concerns for the healthcare and welfare of aging population have been raised. The number of patients with neurological diseases has increased. The diseases have been causing really a great burden for the community, family members and the patient. However, there is no effective way to treat neurodegenerative diseases until now. Therefore, the purpose of this new international partnership project is to study the method of preparation, modification and design surface pattern of the inorganic nanocarbon substrate from Professor Ariga at National Institute for Materials Science (NIMS) in Japan. Moreover, the Taiwanese group has specialized in developing smart waterborne polyurethane with well biocompatibility and insolubility in water. The smart biomaterials can also be used in long-term transplantation in animals, and be absorbed by the body metabolism. Furthermore, the stiffness and degradation rate of the smart materials can be adjusted and easily fine-tuned by the rate of composition. It will be of great potential if the excellent amphiphilic polymeric materials can be combined with the nanocarbon material to develop the useful soft electronic repairing medical devices with physiological characteristics of the transplanted tissue. In this project, we will evaluate the foreign immune response and neural repair capacity of the soft electronic biomaterials and optimize the materials for electrical safety and electromagnetic compatibility criteria both in vitro and in vivo. Upon completion of the project, the Taiwanese group will foster the frontier technology in Taiwan, and carry out patent applications, clinical trial preparation and market research to prepare for production with the Japanese group.組織工程奈米微結構幹細胞新穎性軟電子複合性材料神經退化性疾病tissue engineeringnanostructurestem cellssoft electronic biomaterialsneurological disordersoft electronic biomaterials