Ahsen O.O.Liang K.HSIANG-CHIEH LEEGiacomel Li M.G.Wang Z.Potsaid B.Figueiredo M.Huang Q.Jayaraman V.Fujimoto J.G.Mashimo H.Ahsen O.O.Liang K.Giacomel Li M.G.Wang Z.Potsaid B.Figueiredo M.Huang Q.Jayaraman V.Fujimoto J.G.Mashimo H.2020-10-202020-10-202019https://www.scopus.com/inward/record.uri?eid=2-s2.0-85063238247&doi=10.1055%2fa-0725-7995&partnerID=40&md5=f95064ccb2c37cee7f22cd65fb6aaab7https://scholars.lib.ntu.edu.tw/handle/123456789/517339Background This study aimed to evaluate the use of ultrahigh-speed volumetric en face and cross-sectional optical coherence tomography (OCT) with micromotor catheters for the in vivo assessment of Barrett's esophagus and dysplasia. Methods ?74 OCT datasets with correlated biopsy/endoscopic mucosal resection histology (49 nondysplastic Barrett's esophagus [NDBE], 25 neoplasia) were obtained from 14 patients with Barrett's esophagus and a history of dysplasia and 30 with NDBE. The associations between irregular mucosal patterns on en face OCT, absence of mucosal layering, surface signaľ>subsurface, anď>5 atypical glands on cross-sectional OCT vs. histology and treatment history were assessed by three blinded readers. Results ?Atypical glands under irregular mucosal patterns occurred in 75% of neoplasia (96% of treatment-naïve neoplasia) vs. 30% of NDBE datasets (43% of short- and 18% of long-segment NDBE). Mucosal layering was absent in 35% of neoplasia and 50% of NDBE datasets, and surface signaľ>subsurface occurred in 29% of neoplasia and 30% of NDBE datasets. Conclusions ?Atypical glands under irregular mucosal patterns are strongly associated with neoplasia, suggesting potential markers for dysplasia and a role in pathogenesis. © 2019 Georg Thieme Verlag KG Stuttgart New York.[SDGs]SDG3Article; Barrett esophagus; clinical assessment; controlled study; correlation analysis; disease association; endoscopic mucosal resection; esophageal adenocarcinoma; esophagus biopsy; esophagus dysplasia; esophagus mucosa; gastroesophageal junction; histopathology; human; major clinical study; optical coherence tomography; pathogenesis; priority journal; white light endoscopy; Barrett esophagus; biopsy; diagnostic imaging; esophagoscopy; esophagus mucosa; esophagus tumor; female; male; middle aged; optical coherence tomography; pathology; precancer; procedures; reproducibility; Barrett Esophagus; Biopsy; Esophageal Mucosa; Esophageal Neoplasms; Esophagoscopy; Female; Humans; Male; Middle Aged; Precancerous Conditions; Reproducibility of Results; Tomography, Optical Coherencejournal article10.1055/a-0725-79952-s2.0-85063238247