Kuo, Ching-TaiChing-TaiKuoChuang, Tsung-YuTsung-YuChuangYING-CHIH LIAO2026-02-052026-02-052026-0303009440https://www.scopus.com/record/display.uri?eid=2-s2.0-105025939284&origin=resultslisthttps://scholars.lib.ntu.edu.tw/handle/123456789/735815This study aims to develop a non-toxic and highly biocompatible photocurable bio-based water resistant coating system. Acrylated epoxidized soybean oil (AESO) was selected as the hydrophobic resin, and curcumin was employed as the photoinitiator (PI). The effects of different processing conditions and the addition of various co-initiators (glycerol and 1,6-hexanedithiol) on the crosslinking density and reaction efficiency of the cured films were investigated. The formulation and processing parameters of the coating system were systematically optimized. Kinetic analysis revealed that the system using thiol as the co-initiator exhibited a 66 % higher radical generation rate compared to the glycerol-based system, indicating a significantly improved photopolymerization efficiency. The optimized photoinitiator system (PIS) enabled complete crosslinking within 30 min, achieving a gel fraction exceeding 99 %. Thermogravimetric analysis showed that the T10% of the cured film reached 317.1 °C, with both the gel fraction and thermal stability comparable to those cured with commercial TPO. These results confirm the excellent photocuring performance of the bio-based PIS developed in this study. In addition, biocompatibility tests demonstrated a cell viability of 93 %, confirming the high compatibility of the developed film with biological systems. When applied to various substrates, the coating significantly improved surface hydrophobic stability, with the water contact angle decreasing by only 7–8 degrees within 16 min. Moreover, the water absorption rate was substantially reduced, indicating excellent waterproofing and ink resistance performance. In summary, this study successfully developed a highly reactive and low-toxicity bio-based photocurable water resistant coating system, offering an innovative and promising solution for the development of green water resistant materials.falseBio-derived materialsBiocompatibleCurcuminPhotoinitiatorWater resistant coatingjournal article10.1016/j.porgcoat.2025.1098822-s2.0-105025939284