Zhang, XinruoXinruoZhangBrody, Jennifer AJennifer ABrodyGraff, MariaelisaMariaelisaGraffHighland, Heather MHeather MHighlandChami, NathalieNathalieChamiXu, HanfeiHanfeiXuWang, ZheZheWangFerrier, Kendra RKendra RFerrierChittoor, GeethaGeethaChittoorJosyula, Navya ShilpaNavya ShilpaJosyulaMeyer, MariahMariahMeyerGupta, ShreyashShreyashGuptaLi, XihaoXihaoLiLi, ZilinZilinLiAllison, Matthew AMatthew AAllisonBecker, Diane MDiane MBeckerBielak, Lawrence FLawrence FBielakBis, Joshua CJoshua CBisBoorgula, Meher PreethiMeher PreethiBoorgulaBowden, Donald WDonald WBowdenBroome, Jai GJai GBroomeButh, Erin JErin JButhCarlson, Christopher SChristopher SCarlsonChang, Kyong-MiKyong-MiChangChavan, SameerSameerChavanChiu, Yen-FengYen-FengChiuLEE-MING CHUANGConomos, Matthew PMatthew PConomosDeMeo, Dawn LDawn LDeMeoDu, MengmengMengmengDuDuggirala, RavindranathRavindranathDuggiralaEng, CelesteCelesteEngFohner, Alison EAlison EFohnerFreedman, Barry IBarry IFreedmanGarrett, Melanie EMelanie EGarrettGuo, XiuqingXiuqingGuoHaiman, ChrisChrisHaimanHeavner, Benjamin DBenjamin DHeavnerHidalgo, BerthaBerthaHidalgoHixson, James EJames EHixsonHo, Yuk-LamYuk-LamHoHobbs, Brian DBrian DHobbsHu, DongleiDongleiHuHui, QinQinHuiHwu, Chii-MinChii-MinHwuJackson, Rebecca DRebecca DJacksonJain, DeeptiDeeptiJainKalyani, Rita RRita RKalyaniKardia, Sharon L RSharon L RKardiaKelly, Tanika NTanika NKellyLange, Ethan MEthan MLangeLeNoir, MichaelMichaelLeNoirLi, ChangweiChangweiLiLe Marchand, LoicLoicLe MarchandMcDonald, Merry-Lynn NMerry-Lynn NMcDonaldMcHugh, Caitlin PCaitlin PMcHughMorrison, Alanna CAlanna CMorrisonNaseri, TakeTakeNaseriO'Connell, JeffreyJeffreyO'ConnellO'Donnell, Christopher JChristopher JO'DonnellPalmer, Nicholette DNicholette DPalmerPankow, James SJames SPankowPerry, James AJames APerryPeters, UlrikeUlrikePetersPreuss, Michael HMichael HPreussRao, D CD CRaoRegan, Elizabeth AElizabeth AReganReupena, Sefuiva MSefuiva MReupenaRoden, Dan MDan MRodenRodriguez-Santana, JoseJoseRodriguez-SantanaSitlani, Colleen MColleen MSitlaniSmith, Jennifer AJennifer ASmithTiwari, Hemant KHemant KTiwariVasan, Ramachandran SRamachandran SVasanWang, ZeyuanZeyuanWangWeeks, Daniel EDaniel EWeeksWessel, JenniferJenniferWesselWiggins, Kerri LKerri LWigginsWilkens, Lynne RLynne RWilkensWilson, Peter W FPeter W FWilsonYanek, Lisa RLisa RYanekYoneda, Zachary TZachary TYonedaZhao, WeiWeiZhaoZöllner, SebastianSebastianZöllnerArnett, Donna KDonna KArnettAshley-Koch, Allison EAllison EAshley-KochBarnes, Kathleen CKathleen CBarnesBlangero, JohnJohnBlangeroBoerwinkle, EricEricBoerwinkleBurchard, Esteban GEsteban GBurchardCarson, April PApril PCarsonChasman, Daniel IDaniel IChasmanIda Chen, Yii-DerYii-DerIda ChenCurran, Joanne EJoanne ECurranFornage, MyriamMyriamFornageGordeuk, Victor RVictor RGordeukHe, JiangJiangHeHeckbert, Susan RSusan RHeckbertHou, LifangLifangHouIrvin, Marguerite RMarguerite RIrvinKooperberg, CharlesCharlesKooperbergMinster, Ryan LRyan LMinsterMitchell, Braxton DBraxton DMitchellNouraie, MehdiMehdiNouraiePsaty, Bruce MBruce MPsatyRaffield, Laura MLaura MRaffieldReiner, Alexander PAlexander PReinerRich, Stephen SStephen SRichRotter, Jerome IJerome IRotterBenjamin Shoemaker, MMBenjamin ShoemakerSmith, Nicholas LNicholas LSmithTaylor, Kent DKent DTaylorTelen, Marilyn JMarilyn JTelenWeiss, Scott TScott TWeissZhang, YingzeYingzeZhangHeard-Costa, NancyNancyHeard-CostaSun, Yan VYan VSunLin, XihongXihongLinCupples, L AdrienneL AdrienneCupplesLange, Leslie ALeslie ALangeLiu, Ching-TiChing-TiLiuLoos, Ruth J FRuth J FLoosNorth, Kari EKari ENorthJustice, Anne EAnne EJustice2025-05-142025-05-142025-04-11https://scholars.lib.ntu.edu.tw/handle/123456789/729277Obesity is a major public health crisis associated with high mortality rates. Previous genome-wide association studies (GWAS) investigating body mass index (BMI) have largely relied on imputed data from European individuals. This study leveraged whole-genome sequencing (WGS) data from 88,873 participants from the Trans-Omics for Precision Medicine (TOPMed) Program, of which 51% were of non-European population groups. We discovered 18 BMI-associated signals (P < 5 × 10), including two secondary signals. Notably, we identified and replicated a novel low-frequency single nucleotide polymorphism (SNP) in MTMR3 that was common in individuals of African descent. Using a diverse study population, we further identified two novel secondary signals in known BMI loci and pinpointed two likely causal variants in the POC5 and DMD loci. Our work demonstrates the benefits of combining WGS and diverse cohorts in expanding current catalog of variants and genes confer risk for obesity, bringing us one step closer to personalized medicine.en[SDGs]SDG3journal article10.1038/s41467-025-58420-240216759