Lamonte, GregoryGregoryLamonteTang, XiaohuXiaohuTangChen, Julia Ling-YuJulia Ling-YuChenWu, JianliJianliWuDing, Chien-Kuang CorneliaChien-Kuang CorneliaDingKeenan, Melissa MMelissa MKeenanSangokoya, CarolynCarolynSangokoyaHSIU-NI KUNGIlkayeva, OlgaOlgaIlkayevaBoros, László GLászló GBorosNewgard, Christopher BChristopher BNewgardChi, Jen-TsanJen-TsanChi2020-08-062020-08-062013-12-232049-3002https://scholars.lib.ntu.edu.tw/handle/123456789/511304A variety of oncogenic and environmental factors alter tumor metabolism to serve the distinct cellular biosynthetic and bioenergetic needs present during oncogenesis. Extracellular acidosis is a common microenvironmental stress in solid tumors, but little is known about its metabolic influence, particularly when present in the absence of hypoxia. In order to characterize the extent of tumor cell metabolic adaptations to acidosis, we employed stable isotope tracers to examine how acidosis impacts glucose, glutamine, and palmitate metabolism in breast cancer cells exposed to extracellular acidosis.en[SDGs]SDG310.1186/2049-3002-1-2324359630