Wu M.-H.Chou Y.-C.Yu J.-C.Yu C.-P.Wu C.-C.Chu C.-M.Yang T.Lai C.-H.CHANG-YAO HSIEHYou S.-L.Chen C.-J.Sun C.-A.2020-11-272020-11-2720061047-2797https://www.scopus.com/inward/record.uri?eid=2-s2.0-32944466281&doi=10.1016%2fj.annepidem.2005.02.015&partnerID=40&md5=6f3f23597a3bbcef1022d885c22534ddhttps://scholars.lib.ntu.edu.tw/handle/123456789/522689PURPOSE: This prospective cohort study of 11,889 women was conducted to determine significant factors associated with the risk of breast cancer among Chinese women in Taiwan, a low-incidence area. METHODS: In-person interviews were completed for subjects to solicit information on hormonal factors. Measurements of height, weight, and waist-and- hip circumferences were performed by well-trained assistants using standardized techniques. Cox proportional hazards models were employed to estimate relative risks (RRs) and 95% confidence intervals (CIs). RESULTS: During an average follow-up time of 10.3 years (range: 1 to 11 years) with an accumulation of 134,063 person-years, 104 incident breast cancer cases were identified through data linkage with national cancer registry profile. There was a significant elevation in breast-cancer risk with increasing duration of the interval between age at menarche and age at first full-term pregnancy (FFTP). Additionally, central adiposity reflected by hip circumference was a significant predictor of breast cancer in this Chinese female population. CONCLUSIONS: The findings of this study indicated common mechanisms responsible for the higher incidence of breast cancer in Western populations may also explain the risk of breast cancer development in Taiwan, a low-incidence area. ? 2006 Elsevier Inc. All rights reserved.Body Size; Breast Cancer; Hormonal Risk Factors; Prospective Study[SDGs]SDG3hormone; adult; age; anthropometry; article; body height; body size; body weight; breast cancer; cancer incidence; cancer registry; cancer risk; Chinese; confidence interval; female; human; interview; major clinical study; menarche; obesity; pregnancy; priority journal; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Body Mass Index; Body Size; Breast Neoplasms; China; Cohort Studies; Female; Hormones; Humans; Menarche; Middle Aged; Pregnancy; Proportional Hazards Models; Prospective Studies; Risk Factors; Taiwanjournal article10.1016/j.annepidem.2005.02.015159964842-s2.0-32944466281