SUNG-HSIN KUOChen C.-L.CHIUN-SHENG HUANGANN-LII CHENG2021-09-012021-09-0120000250-7005https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033883122&partnerID=40&md5=ce3ea43fab230ac8ff9e79b1e81b70d3https://scholars.lib.ntu.edu.tw/handle/123456789/580443Metaplastic carcinoma of the breast is a rare form of breast cancer and has an uncertain prognostic significance. Cases from Asian countries have never been reported in the English literature. Between 1983 and 1998, we encountered 8 cases in our institution. There were 7 women and one man with a median age of 52.5 (37-73) years. Pathologic diagnosis included three poorly-differentiated adenosquamous carcinomas, two adenocarcinomas with spindle cell metaplasia, two matrix-producing carcinomas and one carcinosarcoma. Estrogen receptor was positive in 2 (25%) patients. Local recurrence or distant metastasis developed in 3 patients within one year of initial treatment. With a mean follow-up of 81 months (range, 19-183 months), 5 patients were disease-free at the time of this report. Interestingly, two of our patients had presented with huge-sized inflammatory breast cancer and were refractory to neo-adjuvant chemotherapy, but enjoyed an unexpected long disease-free survival after mastectomy. Although the clinical course of our patients appeared in general similar to that of the Western series, the two patients with inflammatory breast carcinoma ran a very unusual course, which may deserve further characterization.[SDGs]SDG3cyclophosphamide; epirubicin; estrogen receptor; fluorouracil; adenosquamous carcinoma; adult; aged; article; Asian; breast adenocarcinoma; breast carcinoma; cancer recurrence; carcinosarcoma; clinical article; female; follow up; human; inflammation; male; mastectomy; metastasis; priority journal; spindle cell; Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Breast Neoplasms, Male; Carcinoma, Adenosquamous; Carcinoma, Ductal, Breast; Carcinosarcoma; Chemotherapy, Adjuvant; Combined Modality Therapy; Cyclophosphamide; Epirubicin; Estrogens; Female; Fluorouracil; Humans; Inflammation; Lymphatic Metastasis; Male; Mastectomy; Metaplasia; Middle Aged; Neoplasm Metastasis; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Progesterone; Receptors, Estrogen; Receptors, Progesterone; Retrospective Studies; Taiwan; Treatment Outcome; Tumor Markers, Biologicaljournal article109281812-s2.0-0033883122