Cheng C.-C.Chang F.-C.Yen H.-C.Lee D.-J.Chiu C.-W.Xin Z.2019-05-142019-05-14201521611653https://scholars.lib.ntu.edu.tw/handle/123456789/408139A breakthrough innovation in water-based polymeric nanoparticles has enabled significant progress in mimicking the folding of natural proteins by generating novel "single-chain polymeric nanoparticles" (SCPNs) via supramolecular interactions. In this study, a practical approach to the living polymerization of functionalized oligo(ethylene glycol) methacrylate monomers allows the incorporation of self-constituted multiple hydrogen-bonded groups into physically cross-linked polymer networks, which enables the formation of highly functionalized SCPNs in an aqueous environment. The newly developed materials are particularly attractive from a practical point of view since they have a very low critical micellization concentration and uniform particle diameters of ca. 25 nm, making them extremely stable under dilute conditions. Concentration-dependent experiments showed that SCPNs formed at polymer concentrations up to 40 mg/mL with no significant change in morphology observed. Moreover, the formed SCPNs had a very high stability in an aqueous solution containing surfactant, suggesting potential for a wide variety of applications as a promising candidate nanocarrier for bioimaging, controlled release, and drug delivery systems. ? 2015 American Chemical Society.journal article10.1021/acsmacrolett.5b005562-s2.0-84946068798https://www.scopus.com/inward/record.uri?eid=2-s2.0-84946068798&doi=10.1021%2facsmacrolett.5b00556&partnerID=40&md5=cc193503419b6fb29360bbd0d8058638