Chen, Chun-HaoChun-HaoChenNai-Kuan ChouSHEY-SHI LUSHI-MING LINHuang, Long-SunLong-SunHuangLin, Shi-MingShi-MingLinChen, Hsiao-ChinHsiao-ChinChenYang, Yu-CheYu-CheYangLin, Yu-TsoYu-TsoLinYu, Shih-AnShih-AnYuNAI-KUAN CHOUWang, Yiao-HongYiao-HongWangChou, Nai-KuanNai-KuanChouLu, Shey-ShiShey-ShiLu2020-03-092020-03-0920090018-9294https://www.scopus.com/inward/record.uri?eid=2-s2.0-63849105471&doi=10.1109%2fTBME.2008.2003262&partnerID=40&md5=aabb9039d0a0544b809ca30cf1931316https://scholars.lib.ntu.edu.tw/handle/123456789/474261A quick wireless label-free detection of disease-related C-reactive proteins (CRPs) using a 200- \mum-long microelectromechanical systems (MEMS) microcantilever housed in a \hbox{7} \times \hbox{7}\ \hbox{mm}^{2} reaction chamber with a safe reusable feature is reported. The assay time ranges from about 30 min to 3 h, depending on accuracy. The deflection of the microcantilever due to specific CRPantiCRP binding is detected using a position-sensitive detector. The converted bio-signal is transmitted by a custom designed wireless amplitude-shift-keying (ASK) transceiver IC fabricated in a 0.18 mu m CMOS process. CRP concentrations from 1 mug/mL to 500 mug/mL can be detected. A 0.2-Hz 1-V ac signal instead of traditional bases/acids is applied to the bio-MEMS sensor to unbind the CRP from the microcantilever for reusability. ? 2006 IEEE.[SDGs]SDG3[SDGs]SDG7Amplitude-shift-keying (ASK) receiver; Analog-to-digital converter (ADC); AntiCRP; ASK transmitter; C-reactive protein (CRP); Label-free; Microcantilever; Microcontrol unit (MCU); Poly-dimethyl-siloxane (PDMS); Atomic force microscopy; Composite micromechanics; Electromechanical devices; Frequency converters; Labels; Microchannels; Microsensors; Multicarrier modulation; Reusability; Silicones; Transmitters; MEMS; C reactive protein; dimeticone; amplitude modulation; analog digital converter; article; human; mathematical analysis; microelectromechanical system; molecular mechanics; process monitoring; protein analysis; protein binding; wireless communication; Biosensing Techniques; C-Reactive Protein; Cardiovascular Diseases; Dimethylpolysiloxanes; Equipment Design; Equipment Reuse; Humans; Micro-Electrical-Mechanical Systems; Monitoring, Ambulatory; Nanotechnology; Signal Processing, Computer-Assistedjournal article10.1109/TBME.2008.200326219342331