Liao C.-H.LI-MIN HUANGCHUN-YI LUCHIN-YUN LEEPO-REN HSUEHPO-NIEN TSAOWU-SHIUN HSIEHTsou K.-I.2021-06-242021-06-2420021608-8115https://www.scopus.com/inward/record.uri?eid=2-s2.0-0036876484&partnerID=40&md5=b7199a1770e0f3f749239f03571224bahttps://scholars.lib.ntu.edu.tw/handle/123456789/566652In this hospital-based review, clinical presentations associated with Group B streptococcus (GBS) infections in children occurring between January 1980 and March 2000 were analyzed. Among the 25 infants with invasive group B streptococcal infections, 9 (36%) were early onset diseases (EOD), 12 (48%) were late onset diseases (LOD), and 4 (16%) occurred beyond the third month of life. Eight of the nine (89%) EOD cases manifested during the first day of life and three (33%) were premature births. Common presentations in GBS infection were fever (75%), poor activity (25%), respiratory distress (25%), lethargy (20%), and irritability (20%). Seizure occurred in 31% of infants with meningitis. Pneumonia (66%) and case-fatality rate (33.3%) were significantly higher in EOD than in LOD. Meningitis was the major manifestation (77%) of LOD and had severe sequelae in 40% of cases. Eight strains were assayed for antibiotic sensitivity and they were all susceptible to penicillin, ampicillin, cefotaxime, and vancomycin. The susceptibilities to erythromycin and clindamycin were 62% and 75%, respectively. Most of the strains from blood or cerebrospinal fluid were type III.[SDGs]SDG3ampicillin; cefotaxime; clindamycin; erythromycin; penicillin G; vancomycin; adolescent; antibiotic sensitivity; article; bacterial strain; cerebrospinal fluid cytology; child; clinical article; clinical feature; controlled study; fever; follow up; high risk population; human; infant; infection rate; infection risk; irritability; lethargy; meningitis; onset age; physical activity; pneumonia; prematurity; respiratory distress; seizure; strain difference; Streptococcus agalactiae; Streptococcus infection; survival rate; Humans; Infant; Infant, Newborn; Retrospective Studies; Streptococcal Infections; Streptococcus agalactiaejournal article126327852-s2.0-0036876484