Hsu, Chin-LinChin-LinHsuChang, Yuan-YenYuan-YenChangCHIH-HSIEN CHIUYang, Kuo-TaiKuo-TaiYangWang, YuYuWangFu, Shih-GueiShih-GueiFuYI-CHEN CHEN2019-09-262019-09-262011-08-010308-8146https://scholars.lib.ntu.edu.tw/handle/123456789/425331Cardiovascular protection of deep-seawater (DSW) drinking water was assessed using high-fat/cholesterol-fed hamsters in this study. All hamsters were fed a high-fat/cholesterol diet (12% fat/0.2% cholesterol), and drinking solutions were normal distiled water (NDW, hardness: 2.48ppm), DSW300 (hardness: 324.5ppm), DSW900 (hardness: 858.5ppm), and DSW1500 (hardness: 1569.0ppm), respectively. After a 6-week feeding period, body weight, heart rates, and blood pressures of hamsters were not influenced by DSW drinking waters. Serum total cholesterol (TC), triacylglycerol (TAG), atherogenic index, and malondialdehyde (MDA) levels were decreased (p<0.05) in the DSW-drinking-water groups, as compared to those in the NDW group. Additionally, increased (p<0.05) serum Trolox equivalent antioxidant capacity (TEAC), and faecal TC, TAG, and bile acid outputs were measured in the DSW-drinking-water groups. Hepatic low-density-lipoprotein receptor (LDL receptor) and cholesterol-7α-hydroxylase (CYP7A1) gene expressions were upregulated (p<0.05) by DSW drinking waters. These results demonstrate that DSW drinking water benefits the attenuation of high-fat/cholesterol-diet-induced cardiovascular disorders in hamsters.enCYP7A1; Cardiovascular protection; Deep seawater; Hamster; LDL receptor; Serum lipid peroxidation; Serum lipids[SDGs]SDG3Cardiovascular protection; CYP7A1; Deep seawater; Hamster; LDL receptor; Serum lipid peroxidation; Serum lipids; Aldehydes; Blood pressure; Body fluids; Cholesterol; Feeding; Gene expression; Glycerol; Hardness; Lipids; Nutrition; Oxidation; Seawater; Potable water; antioxidant; bile acid; cholesterol; cholesterol 7alpha monooxygenase; deep sea water; fat; glyceraldehyde 3 phosphate dehydrogenase; high density lipoprotein cholesterol; hydroxymethylglutaryl coenzyme A reductase; low density lipoprotein receptor; malonaldehyde; messenger RNA; sea water; triacylglycerol; unclassified drug; animal experiment; animal tissue; article; atherogenesis; atherosclerosis; blood level; blood pressure regulation; body weight; cardiovascular disease; cardiovascular protection; cholesterol blood level; cholesterol diet; controlled study; deep sea; diastolic blood pressure; feces level; fluid intake; gene expression regulation; heart protection; heart rate; lipid diet; male; malonaldehyde blood level; nonhuman; protection; Syrian hamster; systolic blood pressure; therapy effect; triacylglycerol blood level; upregulation; Cricetinaejournal article10.1016/j.foodchem.2011.01.116252141072-s2.0-79952536938WOS:000289046300033https://api.elsevier.com/content/abstract/scopus_id/79952536938