YI-TSU CHAN2021-08-032021-08-03202114337851https://www.scopus.com/inward/record.uri?eid=2-s2.0-85096803879&doi=10.1002%2fanie.202010805&partnerID=40&md5=5f0870ed885bd55d762621e65b74c3echttps://scholars.lib.ntu.edu.tw/handle/123456789/575894Supramolecular cages/vesicles in biology display sophisticated structures and functions by utilizing a few types of protein subunit quasi-equivalently at distinct geometrical locations. However, synthetic supramolecular cages still lack comparable complexity to reach the high levels of functionality found in natural systems. Herein we report the self-assembly of giant pentagonal supramolecular prisms (molecular weight >50 kDa) with tetratopic pyridinyl subunits serving different geometrical roles within the structures, and their packing into a novel superstructure with unexpected three-fold rotational symmetry in a single two-dimensional layer of crystalline state. The formation of these complicated structures is controlled by both the predetermined angles of the ligands and the mismatched structural tensions created from the multi-layered geometry of the building blocks. Such a self-assembly strategy is extensively used by viruses to increase the volume and complexity of capsids and would provide a new approach to construct highly sophisticated supramolecular architectures. ? 2020 Wiley-VCH GmbHGeometry; Prisms; Viruses; Building blockes; Complicated structures; Crystalline state; Natural systems; New approaches; Protein subunits; Rotational symmetries; Supramolecular architectures; Supramolecular chemistry[SDGs]SDG3[SDGs]SDG11journal article10.1002/anie.202010805329466492-s2.0-85096803879