CHANG-FENG DAIAhmed, Atallah F.Atallah F.AhmedShiue, Ru-TingRu-TingShiueWang, Guey-HorngGuey-HorngWangDai, Chang-FengChang-FengDaiKuo, Yao-HaurYao-HaurKuoSheu, Jyh-HorngJyh-HorngSheu2018-09-102018-09-102003http://www.scopus.com/inward/record.url?eid=2-s2.0-0042382984&partnerID=MN8TOARShttp://scholars.lib.ntu.edu.tw/handle/123456789/302185Three new norcembrane-based diterpenoids, leptocladolides A (1), B (4) and C (5), along with five known metabolites 6-10, have been isolated from the dichloromethane extract of a Taiwanese soft coral Sinularia leptoclados. Furthermore, a chemical investigation on the dichloromethane extract of S. parva has resulted in the isolation of two new related isomers, 1-epi-leptocladolide A (2) and 7E-leptocladolide A (3), in addition to 1 and 7. The structures of new metabolites 1-5 were elucidated on the basis of extensive spectroscopic analyses and their relative stereochemistries were determined by NOESY experiments. The new metabolites 1 and 3 have been shown to exhibit significant cytotoxic activity against KB and Hepa59T/VGH cancer cell lines. ? 2003 Elsevier Ltd. All rights reserved.application/pdf269308 bytesapplication/pdf1-epi-leptocladolide; 7E-leptocladolide; Leptocladolide A-C; S. parva; Sinularia leptoclados; Soft coral[SDGs]SDG3[SDGs]SDG141 epileptocladolide A; 7e leptocladolide A; cembranoid; dichloromethane; ineleganolide; leptocladolide A; leptocladolide B; leptocladolide C; norcembranoid; scabrolide A; scabrolide D; sinuleptolide; unclassified drug; article; cancer cell culture; coral; cytotoxicity; drug structure; drug synthesis; extraction; human; human cell; nuclear Overhauser effect; priority journal; stereochemistry; Taiwan; Alcyonacea; Anthozoa; Sinulariajournal article10.1016/S0040-4020(03)01138-42-s2.0-0042382984