Chang C.MYu K.JHsu W.LMajor J.MChen J.YPEI-JEN LOULiu M.YDiehl S.RGoldstein A.MChen C.JHildesheim A.2020-10-272020-10-2720120007-0920https://www.scopus.com/inward/record.uri?eid=2-s2.0-84855351607&doi=10.1038%2fbjc.2011.502&partnerID=40&md5=8e0b47fdba23f9708c933174c9b44ec7https://scholars.lib.ntu.edu.tw/handle/123456789/518257Background: To determine whether non-viral nasopharyngeal carcinoma (NPC) risk factors might be associated with (and mediated through) Epstein-Barr virus (EBV) serological responses linked to NPC risk, we evaluated predictors of risk of anti-EBNA1 IgA seropositivity and other markers among unaffected relatives from a large NPC family study in Taiwan. Methods: Multivariate logistic regression conditioned on family was used to examine the associations between sociodemographic, dietary, lifestyle, and occupational variables and risk of anti-EBV EBNA1 IgA positivity, anti-VCA IgA, and anti-DNase positivity. Results: Among 2393 unaffected relatives from 319 multiplex families, 1180 (49.3%) were anti-EBV EBNA1 IgA seropositive. None of the associations with anti-EBNA1 IgA were statistically significant, except for being 31-50 years of age (vs <30, adjusted ORs 0.51-0.57). For one or more EBV serological markers, there were suggestive associations for older age, GuangDong firm salted fish, betel use, current alcohol use, and male gender. Conclusion: Overall, we found little evidence to suggest that non-viral NPC risk factors significantly alter EBV serological patterns, suggesting that non-viral NPC risk factors act through pathways independent of EBV serological responses. ? 2012 Cancer Research UK All rights reserved.DNase; EBNA1; Epstein-Barr virus; IgA; nasopharyngeal carcinoma; VCA[SDGs]SDG3[SDGs]SDG14deoxyribonuclease; Epstein Barr virus antigen 1; immunoglobulin A antibody; virus antibody; adult; alcohol consumption; article; betel nut; cancer risk; demography; diet; disease association; Epstein Barr virus; family study; female; fish; gender; human; lifestyle; major clinical study; male; nasopharynx carcinoma; occupation; predictor variable; priority journal; relative; senescence; serology; Taiwan; Adolescent; Adult; Epstein-Barr Virus Nuclear Antigens; Family; Female; Herpesvirus 4, Human; Humans; Immunoglobulin A; Male; Middle Aged; Nasopharyngeal Neoplasmsjournal article10.1038/bjc.2011.502220952292-s2.0-84855351607