MING-HSIEN HSIEHShan, J.-C.J.-C.ShanHuang, W.-L.W.-L.HuangCheng, W.-C.W.-C.ChengMING-JANG CHIUJaw, F.-S.F.-S.JawHwu, H.-G.H.-G.HwuFU-SHAN JAW2020-11-032020-11-0320120920-9964https://www.scopus.com/inward/record.uri?eid=2-s2.0-84865340158&doi=10.1016%2fj.schres.2012.06.021&partnerID=40&md5=ff38f590f59d3f3286471cda67619dbchttps://scholars.lib.ntu.edu.tw/handle/123456789/519914Background: Recent schizophrenia research exploring the complicated pathogenesis of schizophrenia has focused on the subjects with at-risk mental states in order to exclude the influence of confounding factors. This study explores 3 sets of auditory-related event potentials in subjects with different risk levels of psychosis. Methods: Subjects were recruited from the SOPRES study in Taiwan. P50 and N100 using an auditory paired-click paradigm and duration MMN were assessed on 32 first-episode psychosis (FEP), 30 ultra-high risk (UHR), 37 E-BARS (early/broad at-risk mental states) participants and 56 controls. Results: MMN was correlated with neither P50 nor N100, whereas many parameters of the latter two were intercorrelated with each other. Compared to healthy controls, MMNs were significantly lower in all 3 clinical groups (E-BARS, UHR and FEP). A gradient of sensory-gating deficits, manifested by increased P50 ratios (S2/S1) and decreased N100 differences, across different levels of clinical severity was suggested by a linear trend. For the UHR subjects, P50 gating ratio, N100 gating ratio, N100 difference, and N100. S2 amplitude might be potential indicators to discriminate converters from non-converters. Conclusions: By including subjects with E-BARS, our results provide new insight regarding pre-attentive auditory event-related potential in subjects across different risk levels of psychotic disorders. Impaired deviance detection shown by MMNs already exists in people at a pre-psychotic state regardless of clinical severity, while sensory-gating deficits shown by P50/N100 varies depending on the risk levels in prodromal period. Further longitudinal research exploring the relationship between ERPs and subjects with a suspected pre-psychotic state is needed. ? 2012 Elsevier B.V.[SDGs]SDG3neuroleptic agent; adult; age distribution; amplitude modulation; article; attention; controlled study; disease severity; drug effect; evoked auditory response; female; high risk population; human; latent period; major clinical study; male; mental health; priority journal; psychologic assessment; psychosis; risk assessment; sensory gating; sex difference; Acoustic Stimulation; Adolescent; Adult; Contingent Negative Variation; Electroencephalography; Evoked Potentials, Auditory; Female; Humans; Male; Psychoacoustics; Psychotic Disorders; Reaction Time; Sensory Gating; Taiwan; Young Adultjournal article10.1016/j.schres.2012.06.021227846842-s2.0-84865340158