2020-07-012024-05-15https://scholars.lib.ntu.edu.tw/handle/123456789/664529摘要：為能有效防堵與控制新冠肺炎，急需一種安全、高空間覆蓋率、及高滲透率的消毒方式。SARS-CoV-2新冠肺炎病毒為球狀病毒，球狀奈米結構有量化之結構共振態，由於中心之RNA與外圍之Capsid帶不同電荷，球狀病毒會與微波產生結構共振能量轉換效應，共振微波頻率為所謂l=1 的Acoustic Eigenmode，俗稱dipolar mode。過去實驗證明若照射共振頻率之低劑量微波，可在非熱效應的情況下經由dipolar mode的結構共振能量轉移效應消滅RNA球狀病毒，包含H1N1及H3N2等流感病毒。此共振頻率與病毒大小成反比，能量轉移效率與病毒大小的四次方成正比。由於新冠病毒之半徑約為A型流感病毒的1.5倍，因此預期所需的微波頻率更低，而所需之微波劑量應更小，除微波源易於取得外，輻射量應可符合國際於公共場合規範之安全劑量，就如同手機天線的輻射量一般。 若微波可藉由非熱之結構共振方式將能量轉移至病毒，就有機會以安全低劑量之微波輻射直接藉由巨量結構共振進而破壞病毒結構，進而消滅沾黏在公共場所、在氣凝膠內，或在飛沫內的冠狀病毒。由於微波具高穿透度與高空間覆蓋度，而低劑量微波就如同WIFI機台可長期持續於公共場所發射且無害人體，可提供目前急需之公共場所長時間持續消毒，將極為有助於控制疫情降低擴散。 針對新冠肺炎，本計畫之目標在建立以低劑量微波消毒之相關技術準則。此計畫的主要技術目標有二: 1. 量測新冠病毒之微波共振吸收頻譜，以確認其dipolar mode頻率。 2. 確認消滅新冠病毒所需之微波頻率及其輻射劑量。 除此之外，本計畫亦尋求探討下列事項: 1. 若有後續計畫，是否可於實際應用場域，如加護病房內，確認上述之輻射劑量是否可有效消滅新冠病毒。若可，其protocol為何? 2. 建立國內與國際合作以設計於家用或公共場域，如機艙內、急診室、加護病房內所需之微波輻射源元件。 3. 討論以微波共振吸收早期偵測與治療病患之模型與可行性。 本計畫將可提供目前急需之公共場所(包含機艙、急診室、加護病房、人潮聚集處)長時間持續消除新冠病毒方式，將極為有助於控制COVID-19疫情，降低病毒傳播擴散風險。除此之外，本計畫也可提供可能之早期檢測與肺炎治療方式。<br> Abstract: Respiratory droplet (or even aerosol) transmission is currently treated as the major pathway for SARS-CoV-2 transmission. To kill virus in public space for epidemic prevention, chemical inactivation is currently treated as the most effective way. However strong chemical might affect the public health, while its coverage and penetration are both limited so as to be treated as a thorough and complete disinfection method. A sterilization method with a better penetration capability and space coverage is under urgent demand. Our previous study showed that spherical virus will resonate with microwave at the confined-acoustic dipolar mode of the same frequency. Our recent study further indicated that this structure-resonant energy transfer (SRET) effect from microwaves to virus can be efficient enough so that influenza virus in respiratory droplet or aerosol can be inactivated with reasonable microwave power density safe for the open public. With microwave’s high penetration and high spatial coverage characteristics, our previous results provide an alternative toward establishing a new microwave-based epidemic prevention strategy in open public for SARS-Cov-2 transmission. In this program, we aim to establish a guideline for efficient pathway control of SARS-CoV-2 transmission with low dosage microwave irradiation. To inactivate SARS-CoV-2 using SRET with microwave, the following technical steps are planned under this program 1.The dipolar mode frequencies of SARS-Cov-2 will be determined by using microwave spectrum analyzer through resonance absorption in the lab. 2.At or around the dipolar mode frequency, the microwave-dosage dependent inactivation efficiency will be measured in the lab. Besides these above major items, the following issues will be explored in this program: 1.To confirm and to test the above conclusion, the follow-up plans to test the virus disinfection method in open space should be planned through international collaborations. 2.We will initiate the design and implementation of compact and low-cost microwave sanitizers for various application fields through domestic and international collaboration. 3.We will further explore the possibility to extend our result for early detection and therapy of COVID-19.新冠病毒結構共振能量轉移微波共振吸收消滅病毒病毒檢測SARS-Cov-2Structure resonance energy transfermicrowave resonance absorptionvirus inactivationvirus detection