臺大醫院-內科部;臺大醫學院-微生物學科暨研究所;Cheng, Yi-HsiangYi-HsiangChengLin, Tzu-LungTzu-LungLinPan, Yi-JiunYi-JiunPanWang, Yu-PingYu-PingWangLin, Yi-TsungYi-TsungLinJIN-TOWN WANG2017-02-152018-07-112017-02-152018-07-112015http://ntur.lib.ntu.edu.tw//handle/246246/270673Colistin is one of the antibiotics of last resort for the treatment of carbapenem-resistant Klebsiella pneumoniae infection. This study showed that capsular type K64 (50%) and ST11 (53.9%) are the prevalent capsular and sequence types in the colistin-resistant strains in Taiwan. The interruption of transcripts (38.5%) and amino acid mutation (15.4%) in mgrB are the major mechanisms contributing to colistin resistance. In addition, novel single amino acid changes in MgrB (Stop48Tyr) and PhoQ (Leu26Pro) were observed to contribute to colistin resistance.[SDGs]SDG310.1128/AAC.04763-14