Kao T.-W.CHIEN-CHING HUNGPO-REN HSUEHLin T.-Y.Chen M.-Y.KWEN-TAY LUHChuang C.-Y.2021-12-012021-12-0119970929-6646https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030956364&partnerID=40&md5=304240c889af43c7e24b9d06ec8b6f4chttps://scholars.lib.ntu.edu.tw/handle/123456789/589059Histoplasmosis is one of the most common opportunistic fungal infections in immunocompromoised patients in endemic areas. We report the first two microbiologically documented cases of histoplasmosis in Taiwan. The first patient, with acquired immunodeficiency syndrome and a depleted CD4+ lymphocyte count, presented with a history of prolonged fever, papular skin rashes, pancytopenia and elevation of liver enzymes. He was diagnosed and treated initially for systematic toxoplasmosis, but the microbiologic and pathologic findings of the autopsied specimens disclosed disseminated infection caused by Histoplasma capsulatum. The second patient, an elderly man receiving corticosteroids for adrenal insufficiency, manifested with laryngeal histoplasmosis and was successfully treated with ketoconazole.[SDGs]SDG3ketoconazole; liver enzyme; acquired immune deficiency syndrome; adrenal insufficiency; adult; aged; article; autopsy; case report; clinical feature; corticosteroid therapy; enzyme assay; fever; helper cell; histoplasma capsulatum; histoplasmosis; human; immune deficiency; immunocompetent cell; lymphocyte count; male; opportunistic infection; pancytopenia; rash; taiwan; Adult; Aged; AIDS-Related Opportunistic Infections; Histoplasmosis; Humans; Male; Opportunistic Infections; Taiwanjournal article91708272-s2.0-0030956364