PANG-SHUO HUANGJEN-FANG CHENGLi, Guan-WeiGuan-WeiLiChuang, Eric YEric YChuangJIEN-JIUN CHENChiu, Fu-ChunFu-ChunChiuCHO-KAI WUYI-CHIH WANGJUEY-JEN HWANGCHIA-TI TSAI2023-06-122023-06-122023-05-191099-5129https://scholars.lib.ntu.edu.tw/handle/123456789/632612Atrial fibrillation (AF) is one of the major causes of ischaemic stroke. In addition to clinical risk evaluated by the CHA2DS2-VASC score, the impact of genetic factors on the risk of AF-related thromboembolic stroke has been largely unknown. We found several copy number variations (CNVs) in novel genes that were associated with thromboembolic stroke risk in our AF patients by genome-wide approach. Among them, the gasdermin D (GSDMD) gene was related to inflammation. We aimed to test whether GSDMD deletion was associated with AF-related stroke.enAtrial fibrillation • Stroke • Genetic study • GSDMD • Asiajournal article10.1093/europace/euad103370832552-s2.0-85160876347WOS:000971483300001