CHI-KUANG SUN2018-09-102018-09-10200301469592http://www.scopus.com/inward/record.url?eid=2-s2.0-0345761525&partnerID=MN8TOARShttp://scholars.lib.ntu.edu.tw/handle/123456789/303121https://www.scopus.com/inward/record.uri?eid=2-s2.0-0345761525&doi=10.1364%2fOL.28.002488&partnerID=40&md5=d0564935e98e6fead44bbb53d0e54fd7Because it avoids the in-focus photodamage and phototoxicity problem of two-photon-fluorescence excitation, multiharmonic-generation biopsy based on a 1200-1300-nm light source could provide a truly noninvasive and highly penetrative optical sectioning of skin. We study multiharmonic-generation biopsy of fixed mouse skin. Our preliminary study suggests that this technique could provide submicrometer-resolution deep-tissue noninvasive biopsy images in skin without the use of fluorescence and exogenous markers.Biopsy; Fluorescence; Harmonic generation; Laser damage; Light absorption; Light scattering; Medical imaging; Noninvasive medical procedures; Photons; Skin; Solid state lasers; Telescopes; Multiharmonic generation biopsy; Optical sectioning; Photodamage; Phototoxicity; Two photon fluorescence excitation; Two photon imaging; Laser tissue interactionjournal article2-s2.0-0345761525