外科HUANG, CHIUN-SHENGCHIUN-SHENGHUANGCHANG, KING-JENKING-JENCHANG2008-12-222018-07-112008-12-222018-07-111998http://ntur.lib.ntu.edu.tw//handle/246246/92799Angiogenesis plays an important role in tumor growth and metastasis. We performed an immunohistochemical study by anti-CD31 antibody to investigate the prognostic significance of microvessel count (MVC) in 163 Taiwanese patients with primary invasive ductal breast carcinomas. Univariate analysis revealed that MVC per 200× field correlated significantly with disease-free (P < 0.001) and overall survival (P < 0. 0008). In 74 patients with node- negative tumors, MVC also significantly correlated with disease-free (P < 0.03) and overall survival (P < 0.007). Multivariate Cox regression analysis demonstrated that MVC is an independent factor in predicting disease-free (P < 0. 02) and overall survival (P < 0.02). Our study confirms that tumor angiogenesis as measured by MVC is a reliable independent prognostic factor of breast cancer.en-US[SDGs]SDG3journal article