Wang C.-Y.Sun S.-W.SHOEI-SHENG LEE2021-07-162021-07-162004320943https://www.scopus.com/inward/record.uri?eid=2-s2.0-11944271720&doi=10.1055%2fs-2004-835845&partnerID=40&md5=9b3e2519040d9b9c7df564375c33831fhttps://scholars.lib.ntu.edu.tw/handle/123456789/571462The pharmacokinetics and metabolism of retrojusticidin B, an anti-HIV reverse transcriptase agent isolated from Phyllanthus myritifolius, were studied in rats. The phase II conjugated metabolites were characterized after solvolysis and enzymatic hydrolysis. The oral bioavailabilities of retrojusticidin B, suspended in Tween 80 and in corn oil, were found to be 22.1 % and 33.1 %, respectively. The elimination half-lives (T1/2) were 22.9 and 36.2 minutes, respectively. The T1/2, clearance, and the volume of distribution (Vz) of retrojusticidin B estimated from i.v. measurements were 24.5 min, 2.6 ± 0.4 L/min, and 90.6 ± 6.4 L, respectively. 9,9′-Secoretrojusticidin B was shown to be phase 1 metabolite.Bioavailability; Metabolites; Pharmacokinetics; Retrojusticidin B[SDGs]SDG3antivirus agent; corn oil; drug metabolite; lignan derivative; plant extract; polysorbate 80; retrojusticidin B; unclassified drug; animal experiment; animal tissue; article; controlled study; drug bioavailability; drug clearance; drug distribution; drug elimination; drug half life; drug metabolism; female; hydrolysis; male; nonhuman; Phyllanthus; rat; solvolysis; Administration, Oral; Animals; Anti-HIV Agents; Biological Availability; Corn Oil; Female; Infusions, Intravenous; Lignans; Naphthalenes; Phyllanthus; Phytotherapy; Polysorbates; Rats; Rats, Wistar; Animalia; Zea maysjournal article10.1055/s-2004-835845156435512-s2.0-11944271720