LI-YING WANGLuo H.-J.Hsieh W.-S.Hsu C.-H.Hsu H.-C.PEI-SHAN CHENChiu N.-C.WANG-TSO LEESUH-FANG JENG2020-06-292020-06-2920108755-6863https://www.scopus.com/inward/record.uri?eid=2-s2.0-75849118551&doi=10.1002%2fppul.21171&partnerID=40&md5=bd62a227fc9467db1d93e36d4468d3ebhttps://scholars.lib.ntu.edu.tw/handle/123456789/506319Oral feeding has been reported to compromise breathing among preterm infants with bronchopulmonary dysplasia (BPD) during hospitalization or shortly after discharge. However, limited information was available concerning whether preterminfants with BPD remain vulnerable to feeding and growth insufficiency after a longer term of follow-up. The purpose of this study was therefore to examine the effect of severity of BPD on pulse oxygen saturation (SpO 2) during feeding and growth in very low birth weight (VLBW) preterm infants during infancy. Seventy-two preterm infants with VLBW and 15 terminfants were prospectively examined their growth and SpO2 during feeding at 2, 4, and 6 months of corrected age. The severity of BPD was graded in VLBW infants according to the American National Institutes of Health consensus definition. In comparison to VLBW infants with mild BPD and terminfants, VLBW infants with severe BPD showed significantly lower mean levels of SpO 2 during feeding at 2-6 months corrected age (P<0.05). Those with severe BPD further exhibited higher rates of growth delay (weight<10th percentile) throughout the study period. Among VLBW infants, severe BPD had an adverse relation with subsequent weight measures after adjustment for medical and demographic confounding variables (β=-904 g, P=0.03). The consensus BPD definition is useful to identify those preterm infants who are at greater risk of feeding desaturation and growth delay during infancy and close monitoring of SpO2 during feeding should be advised. ? 2010 Wiley-Liss, Inc.[SDGs]SDG3indometacin; adverse outcome; article; birth weight; child growth; consensus; controlled study; disease severity; female; growth retardation; heart surgery; high risk infant; human; infancy; infant; infant feeding; lung dysplasia; major clinical study; male; oxygen saturation; patent ductus arteriosus; prematurity; priority journal; prospective study; very low birth weight; Bronchopulmonary Dysplasia; Child Development; Female; Gestational Age; Humans; Infant; Infant Nutrition Disorders; Infant, Newborn; Infant, Premature; Infant, Very Low Birth Weight; Longitudinal Studies; Male; Oxygen; Riskjournal article10.1002/ppul.21171200548612-s2.0-75849118551