廖漢文2006-07-262018-07-122006-07-262018-07-121999-07-31http://ntur.lib.ntu.edu.tw//handle/246246/25421長期以來，肝素被使用作為抗凝劑及治療血管栓塞。然由於一般傳 統使用的肝素分子較大、其只能作用於血管腔內。但近年來有所謂小分子肝素的 發明，其分子大小為原來的約三分之一。此一種肝素有被使用於治療腦中風缺血 病人，並報告有較佳的預後結果。唯其機轉仍未明瞭。吾等設計使用小白鼠中腦 動脈缺血模型作研究比較傳統肝素和小分子肝素對梗塞大小的影響及其預後結 果。此實驗共分五組，分別為﹕對照組，栓塞一小時組，栓塞四小時組、後兩組 分別再施以傳統肝素和小分子肝素治療。在治療一天後評估彼等組織學上梗塞範 圍的大小差異。以瞭解彼等臨床差異的基本機轉。 結果﹕在以小分子肝素治療的一小時梗塞實驗組在從較上明顯的梗塞 面減少（0.13cc ± 0.07 vs 0.27cc ± 0.11）。但在以小分子肝素治療的四小時梗塞實 驗組的差異並不明顯（0.24cc± 0.14 vs 0.30cc± 0.05）。Shortly after the ischemic attack (<6 hours), we can use different kinds of medicine, or instruments to re-build the cerebral circulation, and this possibly reduces the neurological deficit, and also the burden of the family and the society. Heparin is a kind of anti-coagulant. It has been used for the treatment of vascular occlusion for a long time. However, since the molecules of conventional heparin (CH) is large, and they can be used only in intravascular route. Low molecular weight heparin (LMWH) has a molecular size as small as 1/3 of the CH. It has been used in the treatment of cerebral ischemic stroke, and has a better outcome though its mechanism is unclear. In this study, we plan to compare the effect of CH and LMWH in a cerebral ischemia rat model. The animal will be divided into the following groups: (1) sham-control; (2) ischemia for 1 hour then treated with CH, (3) ischemia for 1 hours then treated with LMWH, (4) Ischemia for 4 hours then treated with CH, (5) Ischemia for 4 hours then treated with LMWH. The animals will be sacrified 1 day later after a neurlogical evaluation. We compared their histologic infarct volume with statistic methods. Result: The different between the treatment with LMWH and conventional heparin in the groups with 1 hour ischemia is significant (0.13cc ± 0.07 vs 0.27cc ± 0.11). However, the different in the groups with 4 hours ischemia is not significant （0.24cc± 0.14 vs 0.30cc± 0.05）。application/pdf144633 bytesapplication/pdfzh-TW國立臺灣大學醫學院放射線科腦缺血梗塞動物肝素Cerebral IschemicInfarctanimalheparinjournal articlehttp://ntur.lib.ntu.edu.tw/bitstream/246246/25421/1/882314B002131.pdf