Autoregulating cerebral tissue selfishly exploits collateral flow routes through the circle of willis

Kennedy McConnell F.A.Payne S.J.STEPHEN JOHN PAYNE2022-05-242022-05-242018https://www.scopus.com/inward/record.uri?eid=2-s2.0-85042937127&doi=10.1007%2f978-3-319-65798-1_54&partnerID=40&md5=9743d1bc37511fa5a644d8c0ce48239fhttps://scholars.lib.ntu.edu.tw/handle/123456789/611748Objective: Ischemic stroke is a leading cause of death and disability. Autoregulation and collateral blood flow through the circle of Willis both play a role in preventing tissue infarction. A steady-state model of the cerebral arterial network was used to investigate the interaction of these mechanisms when autoregulation is impaired ipsilateral to an occluded artery. Materials and methods: Twelve structural variants of the circle of Willis were modelled with left internal carotid artery occlusion and coupled with (1) a passive model of the cerebral vascular bed, (2) a steady-state model of an autoregulating cerebral vascular bed, and (3) a model in which the contralateral hemisphere autoregulates and the ipsilateral hemisphere does not. Results: Results showed that if the autoregulatory response is impaired ipsilaterally, then, in the autoregulating hemisphere, cerebral flows are preserved at the expense of those on the ipsilateral side. Conclusions: Thus, although autoregulation is an essential facilitator of collateral flow through the circle of Willis, contralateral autoregulation can exacerbate flow reductions if not balanced by the same response in the vascular beds on the ipsilateral side. The status of the autoregulatory response in both hemispheres can strongly influence cerebral blood flows and tissue survival and should, therefore, be monitored in stroke. ? Springer International Publishing AG 2018.autoregulationbrain blood flowbrain blood vesselbrain circulus arteriosusbrain ischemiabrain tissuecapillary resistancecollateral circulationhemisphereinternal carotid arteryinternal carotid artery occlusionnegative feedbacktissue survivalvascular resistanceanatomical variationanatomy and histologybiological modelbrain circulationbrain infarctioncarotid artery diseasecerebrovascular accidentcerebrovascular diseasehomeostasishumanpathophysiologyphysiologyAnatomic VariationBrain InfarctionCarotid Artery DiseasesCarotid Artery, InternalCerebrovascular CirculationCerebrovascular DisordersCircle of WillisCollateral CirculationHomeostasisHumansModels, CardiovascularStroke[SDGs]SDG3Autoregulating cerebral tissue selfishly exploits collateral flow routes through the circle of willisbook part10.1007/978-3-319-65798-1_542-s2.0-85042937127