Kuo R.-C.Lin H.-P.Sun A.YI-PING WANG2021-07-072021-07-0720130929-6646https://www.scopus.com/inward/record.uri?eid=2-s2.0-84875600186&doi=10.1016%2fj.jfma.2012.01.014&partnerID=40&md5=ba50706a78938e360a65984cfbd8e39fhttps://scholars.lib.ntu.edu.tw/handle/123456789/570288Background/Purpose: Erosive oral lichen planus (EOLP) is a T-cell-mediated inflammatory disease that is refractory to treat. This study tested whether local injection of triamcinolone acetonide plus oral administration of low- or medium-dose prednisolone could hasten the healing of EOLP lesions. Methods: In this study, 50 EOLP patients were treated with local injection of Kenacort A (40. mg triamcinolone acetonide once weekly for 3 and 2 weeks for 30 major and 20 minor EOLP patients, respectively) plus oral administration of prednisolone (25-30. mg and 15-20. mg of prednisolone once daily for 2 weeks for 30 major and 20 minor EOLP patients, respectively). The oral administration of prednisolone was tapered to 5. mg per day and stopped in 7 days. Then, the patients were treated with topical Dexaltin (0.1% dexamethasone, once or twice per daily) and oral administration of vitamin Bc (one capsule twice daily) thereafter. Results: After 3-week treatments, the 30 major EOLP patients showed complete response (lack of detectable erosive or ulcerative lesion with absence or regression of reticular or papular OLP) in 27 cases (90%) and partial response (reduction of erosive or ulcerative lesion by at least 30% in diameter with regression of reticular or papular OLP) in cases (10%); and 20 minor EOLP patients demonstrated complete response in 18 cases (90%) and partial response in two cases (10%). However, all the 45 complete response major or minor EOLP patients showed recurrence of erosive or ulcerative lesion after 3-24 (mean 12) months of follow-up. Conclusion: Prompt and complete healing of the EOLP lesions could be achieved in a relative short period of time after treatment with our protocol. Although complete response EOLP lesions recurred after a follow-up period of 3-24 months, patients did have an average remission period of 12 months after treatment with our protocol. ? 2012.Erosive oral lichen planus; Local corticosteroid injection; Treatment[SDGs]SDG3dexaltin; dexamethasone; folic acid; prednisolone; triamcinolone acetonide; unclassified drug; adult; aged; article; clinical article; corticosteroid therapy; female; follow up; healing; human; lichen planus; low drug dose; male; recurrent disease; remission; treatment response; Adult; Aged; Drug Therapy, Combination; Female; Humans; Lichen Planus, Oral; Male; Middle Aged; Prednisolone; Triamcinolone Acetonidejournal article10.1016/j.jfma.2012.01.014235378682-s2.0-84875600186