WEI-SHIUNG YANGTsou, Pei-LingPei-LingTsouLee, Wei-JeiWei-JeiLeeTseng, Da-LunDa-LunTsengCHI-LING CHENPeng, Chi-ChungChi-ChungPengLee, Kuan-ChingKuan-ChingLeeChen, Mei-JuMei-JuChenHuang, Chang-JenChang-JenHuangTONG-YUAN TAILEE-MING CHUANG2023-02-082023-02-082003-070946-2716https://scholars.lib.ntu.edu.tw/handle/123456789/627678Adiponectin gene polymorphisms have recently been reported to be associated with obesity, insulin sensitivity, and the risk of type 2 diabetes. We examined a T94G polymorphism of the adiponectin gene in 245 ostensibly normal nondiabetic subjects. The G allele frequency was lower among subjects with higher BMI (> or =27) than in those with lower BMI. BMI was inversely correlated with the dose of G allele. Multivariate linear regression analyses showed that the adiponectin genotypes were significantly related to BMI after adjusting for age and gender. The dose of the G allele was associated with a reduction of approximately 1.12 kg/m(2) in BMI. We further found that the relative mRNA levels of G allele were consistently higher than those of T allele in the omental adipose tissue from 21 heterozygous subjects. Finally, we observed that the expression levels of adiponectin affected insulin-stimulated glucose uptake in differentiated 3T3-L1 adipocytes. In conclusion, the allele-specific differential expression of this common polymorphism could be responsible for its biological effects observed in this and the other studies.enobesity; insulin resistance; adiponectin; polymorphism; mRNA; INSULIN-RESISTANCE SYNDROME; ADIPOSE-SPECIFIC PROTEIN; PLASMA-PROTEIN; ASSOCIATION; WEIGHT; SENSITIVITY; MACROPHAGES; ADIPOCYTES; MUTATIONS; PATHWAYjournal article10.1007/s00109-002-0409-4127508192-s2.0-10744230063WOS:000184091700006https://api.elsevier.com/content/abstract/scopus_id/10744230063