Ji, You-RenYou-RenJiYoung, Tai-HorngTai-HorngYoungTsai, Ting-YuTing-YuTsaiJIN-SHING CHENKE-CHENG CHEN2022-10-062022-10-062021-092373-9878https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114344256&doi=10.1021%2facsbiomaterials.1c00512&partnerID=40&md5=a6a9c7fd10c1390142bfa792895aabachttps://scholars.lib.ntu.edu.tw/handle/123456789/623394It is important to mark an early lung tumor manifested with small nodules during computed tomography-guided and minimally invasive surgery. The aim of this study is to develop an injectable hydrogel for clinical lung nodule localization. Dopamine, a typical catechol-containing compound, was used to modify alginate for better gel formation and performance needed for localization application. Through the addition of an adequate oxidant and catalase, the catechol-conjugated alginate (C-ALG) hydrogel showed rapid gelation for less than 5 min, similar mechanical properties to lung tissue, slight swelling degree, good cell compatibility, and enough tissue adhesion for localization around the lung tissue. In addition, the C-ALG hydrogel increased the bursting pressure of lung tissue up to 266 ± 15-385 ± 13 mm-H2O that could prevent hydrogel rupture and migration during localizing surgery, suggesting the injectable hydrogel with effectiveness and safety for clinical applications. © 2021 American Chemical Societyenjournal article10.1021/acsbiomaterials.1c00512344059972-s2.0-85114344256