Unnikrishnan BGultom I.STseng Y.-THUAN-TSUNG CHANGHuang C.-C.2022-04-252022-04-25202100219797https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104611125&doi=10.1016%2fj.jcis.2021.04.035&partnerID=40&md5=b7aaccb922fd402e21041d44cb6e5683https://scholars.lib.ntu.edu.tw/handle/123456789/606882We report a one-pot, room-temperature, morphology-controlled synthesis of titanium oxide (TiOx)–gold nanocomposites (TiOx–Au NCs) using HAuCl4 and TiCl3 as precursors, and catechin as reducing agent. TiOx–Au NCs have a range of morphologies from star-like to urchin-like shape depending on the concentration of TiCl3 in the reaction mixture. The urchin-shaped TiOx–Au NCs exhibited excellent photocatalytic activity toward dye degradation due to strong light absorption, plasmon-induced excitation, high conductivity of the gold, and reduced hole-electron pair recombination. TiOx–Au NCs have the advantage of a wide range of light absorption and surface plasmon absorption-mediated excitation due to their abundant gold spikes, which enabled the degradation of dyes over 97% in 60 min, using a xenon lamp as a light source. In addition, TiOx–Au NCs are highly efficient for the photoinactivation of Escherichia coli and methicillin-resistant Staphylococcus aureus (MRSA), and Candida albicans through the photodynamic generation of reactive oxygen species (ROS) and damage to the bacterial membrane. The catechin derivatives on the NCs effectively promoted curing MRSA infected wounds in rats through inducing collagen synthesis, migration of keratinocytes, and neovascularization. ? 2021 Elsevier Inc.Bacterial inactivationDye degradationOne-step synthesisPlasmon-induced sensitizationRadicalsBiodegradationChlorine compoundsDyesElectric lampsEscherichia coliFlavonoidsGoldLight absorptionMorphologyPhenolsPhotocatalytic activitySurface plasmonsTitanium oxidesCatechin derivativesExcellent photocatalytic activitiesMethicillin-resistant staphylococcus aureusMorphology evolutionMorphology-controlledNeo-vascularizationPhoto catalytic degradationSurface plasmon absorptionGold compoundscatechincollagengold nanoparticlegold nanourchinradicalreactive oxygen metabolitetitanium dioxideunclassified drugwound healing promoting agentcoloring agentgoldmetal nanoparticletitaniumA-549 cell lineanimal cellanimal experimentanimal modelantibacterial activityArticlebacterial membranebacterium culturebiocompatibilityCandida albicanscell migrationcollagen synthesisconductancecontrolled studydegradationexcitationHEK293T cell lineHep-G2 cell linehumanhuman cellin vivo studykeratinocytelightlight absorptionmalemethicillin resistant Staphylococcus aureusmethicillin resistant Staphylococcus aureus infectionmouseneovascularization (pathology)NIH 3T3 cell linenonhumanphotocatalysispriority journalratsurface plasmon resonancewound healingwound infectionanimalAnimalsColoring AgentsMetal NanoparticlesMethicillin-Resistant Staphylococcus aureusRatsTitanium[SDGs]SDG3journal article10.1016/j.jcis.2021.04.035339018512-s2.0-85104611125