Lee, Wei-TingWei-TingLeeKE-CHENG CHENCHING-YAO YANGYeh, Yu-ChengYu-ChengYehYEN-HENG LINHuang, Yu-ChengYu-ChengHuangJO-YU CHENJIN-SHING CHENFON-YIH TSUANG2026-04-132026-04-132026-03-23https://scholars.lib.ntu.edu.tw/handle/123456789/737104Historically, stage T4 non-small cell lung cancer (NSCLC) with direct spinal invasion was considered a definitive surgical contraindication due to the perceived inability to achieve negative margins without catastrophic morbidity. This paradigm has shifted through the advancement of specialized surgical techniques, which facilitate radical en-bloc resection in highly selected candidates by adhering to the en-bloc concept. This concept mandates the retrieval of the tumor and invaded vertebral segments as a single, contiguous unit to prevent intralesional transgression and local recurrence. Achieving microscopic negative margins (R0) stands as the most critical prognostic factor, as radical resection offers a significantly improved potential for long-term survival. Technical success requires a meticulously planned multidisciplinary approach encompassing varied surgical corridors-ranging from combined anterior-posterior windows to single-stage posterior-only approaches-tailored to the tumor's anatomical level. Furthermore, preoperative hemostatic optimization using dual-energy computed tomography (DECT) for vascular assessment and transarterial embolization (TAE) has become indispensable for managing the hypervascularity of the invaded vertebral bone. This review synthesizes these evolving strategies, illustrated by a case of a 74-year-old male with stage T4 NSCLC where an R0 resection was achieved through a two-stage approach integrating uniportal video-assisted thoracoscopic surgery (VATS). Ultimately, en-bloc management provides a feasible and potential surgical strategy toward long-term survival for localized, spine-invasive lung cancer within a multidisciplinary treatment framework.enR0 resectionen-bloc resectionspine invasionstage T4 lung cancerreview article10.3390/biomedicines1403073341898377