CHIH-CHIEH CHANHsiao C.-H.TSEN-FANG TSAI2020-10-222020-10-2220071027-8117https://www.scopus.com/inward/record.uri?eid=2-s2.0-34250723199&partnerID=40&md5=9c39a5d3c1eecdc07c08a905c8821887https://scholars.lib.ntu.edu.tw/handle/123456789/517716Monilethrix, a rare congenital trichodystrophy, is characterized by fragility of scalp hair with partial or total alopecia. Affected individuals may have a variable degree of follicular hyperkeratosis and nail changes. Some monilethrix has been reported to be associated with genetic mutations on human keratins. Mutation in DSG4 has also been reported. Some patients could find a family association. To date, several treatments have been introduced. However, there is still no effective treatment for the disease.enAlopecia; Beaded hair; Keratin; Monilethrix[SDGs]SDG3cadherin; keratin; protein dsg4; unclassified drug; adolescent; alopecia; article; case report; clinical feature; congenital malformation; Darier disease; gene mutation; human; male; monilethrix; nail disease; physical examination; pruritus; rare disease; scalp hair; scanning electron microscope; skin fragilityjournal article2-s2.0-34250723199