JIN-MING WUCHING-YAO YANGTING-CHUN KUOHONG-SHIEE LAIChiang P.-Y.Hsieh S.-H.YU-WEN TIEN2020-09-292020-09-2920150364-2313https://scholars.lib.ntu.edu.tw/handle/123456789/515670Background: The change in the route of food passage after pancreaticoduodenectomy (PD) is quite similar to the change after gastric bypass surgery; both procedures bypass the duodenum and directly connect to the distal jejunum. Moreover, both procedures result in resolution of type 2 diabetes mellitus. Therefore, more distal enteral anastomosis after PD may further improve glycemic status. Methods: To test the effect of distal enteral feeding on glucose metabolism in patients after PD, we performed a meal test on 20 patients via a nasogastric tube [proximal feeding group (PFG)] on post-operative day 5 and then via an intra-operatively placed jejunostomy feeding tube [distal feeding group (DFG)] on post-operative day. Blood samples were assessed for hormones and glucose. Results: The AUC0-120 min levels of GLP-1, C-peptide, and insulin after distal feeding were significantly higher than after proximal feeding. The AUC0-120 min levels of glucose in the DFG were significantly lower than in the PFG. Conclusions: More distal enteral feeding contributed to better glucose metabolism after PD. ? 2015 Soci?t? Internationale de Chirurgie.[SDGs]SDG3C peptide; glucagon like peptide 1; glucose blood level; insulin; adult; aged; blood; digestive tract intubation; enteric feeding; female; glucose blood level; human; jejunostomy; male; metabolism; middle aged; pancreaticoduodenectomy; physiology; postprandial state; procedures; very elderly; Adult; Aged; Aged, 80 and over; Blood Glucose; C-Peptide; Enteral Nutrition; Female; Glucagon-Like Peptide 1; Humans; Insulin; Intubation, Gastrointestinal; Jejunostomy; Male; Middle Aged; Pancreaticoduodenectomy; Postprandial Periodjournal article10.1007/s00268-015-3157-7262022902-s2.0-84942983904