YING-CHENG CHIANGChen Y.-Y.Hsieh S.-F.CHUN-JU CHIANGYou S.-L.WEN-FANG CHENGLai M.-S.CHI-AN CHENTaiwan Cervical Cancer Prevention Surveillance Center2021-02-042021-02-0420171028-4559https://www.scopus.com/inward/record.uri?eid=2-s2.0-85021736154&doi=10.1016%2fj.tjog.2017.01.010&partnerID=40&md5=d15184134c7aad43f307ab0e90905dcahttps://scholars.lib.ntu.edu.tw/handle/123456789/548460Objective To evaluate the influence of age, screening interval, and histologic type on the effect of Pap smears in cervical cancer screening. Materials and methods Data were retrieved from the Taiwan National Cancer Registry and Cervical Cancer Screening Registration System for the period from 2002 to 2010. Age, Pap smear interval, FIGO stage, and histology were further analyzed. Results A total of 12,294 women with cervical cancer were enrolled, including 10,040 with squamous cell carcinoma (SCC), 1720 with adenocarcinoma (ADC), 401 with adenosquamous carcinoma (ASC), and 133 with small cell neuroendocrine carcinoma (SMC). Women who had a Pap smear at an interval of <3 years had a significantly higher proportion of stage I disease than women who had never undergone cervical cancer screening (p < 0.0001). Greater than 40% of women with SCCs in each age group had never had a Pap smear; however, women with ADCs were predominantly in the younger age and greater than 40% of women with ADCs had Pap smear at intervals < 3 years. Conclusions Pap smear is more effective in screening for cervical SCCs compared to cervical ADCs. Improving adherence to screening recommendations is important for the prevention of cervical SCC, especially in elderly women. ? 2017[SDGs]SDG3[SDGs]SDG5adenosquamous carcinoma; adult; aged; Article; cancer registry; cancer screening; cancer staging; cohort analysis; controlled study; female; groups by age; human; human tissue; major clinical study; medical history; neuroendocrine carcinoma; Papanicolaou test; Taiwan; tissue section; uterine cervix carcinoma; adenocarcinoma; age; early cancer diagnosis; mass screening; middle aged; pathology; procedures; register; squamous cell carcinoma; statistics and numerical data; time factor; uterine cervix; uterine cervix tumor; vagina smear; Adenocarcinoma; Adult; Age Factors; Aged; Carcinoma, Squamous Cell; Cervix Uteri; Cohort Studies; Early Detection of Cancer; Female; Humans; Mass Screening; Middle Aged; Papanicolaou Test; Registries; Taiwan; Time Factors; Uterine Cervical Neoplasms; Vaginal Smearsjournal article10.1016/j.tjog.2017.01.010288055982-s2.0-85021736154