Y.-C. SyuW.-E. HsuC.-T. LinCHIH-TING LIN2019-10-242019-10-24201821628769https://scholars.lib.ntu.edu.tw/handle/123456789/428232Biosensor research has been addressed as an interested field recently. Within different kinds of developed biosensing technologies, field-effect transistor (FET) based biosensors stand out due to their attractive features, such as ultra-sensitivity detection, massproduction capability, and low-cost manufacturing. To promote understandings of the FET based biosensing technology, in this review, its sensing mechanism is introduced, as well as major FET-based biosensing devices: ion sensitive field-effect transistor (ISFET), silicon nanowire, organic FET, graphene FET, and compound-semiconductor FET. In addition to FET-based biosensing devices, clinical applications, such as cardiovascular diseases (CVDs), cancers, diabetes, HIV, and DNA sequence, are also reviewed. In the end, several critical challenges of FET-based biosensing technology are discussed to envision next steps in healthcare technologies. ? The Author(s) 2018. Published by ECS.[SDGs]SDG3[SDGs]SDG9Biosensors; Diseases; Graphene transistors; Ion sensitive field effect transistors; Biosensing devices; Cardio-vascular disease; Clinical application; Compound semiconductors; Critical challenges; Healthcare technology; Low cost manufacturing; Sensitivity detection; Transistorsjournal article10.1149/2.0291807jss2-s2.0-85051364230