HSIEN-SHUN LIAOJING-JER LINLiu, YangYangLiuHuang, PengPengHuangJin, AlbertAlbertJinChen, XiaoyuanXiaoyuanChen2019-10-092019-10-092016-08-042040-3364https://scholars.lib.ntu.edu.tw/handle/123456789/426463We report the investigation of the self-assembly mechanism of nanofibers, using a small peptide amphiphile (NapFFKYp) as a model. Combining experimental and simulation methods, we identify the self-assembly pathways in the solution and on the substrates, respectively. In the solution, peptide amphiphiles undergo the nucleation process to grow into nanofibers. The nanofibers can further twist into high-ordered nanofibers with aging. On the substrates, peptide amphiphiles form nanofibers and nanosheet structures simultaneously. This surface-induced nanosheet consists of rod-like structures, and its thickness is substrate-dependent. Most intriguingly, water can transform the nanosheet into the nanofiber. Molecular dynamic simulation suggests that hydrophobic and ion-ion interactions are dominant forces during the self-assembly process.en[SDGs]SDG3[SDGs]SDG6journal article10.1039/c6nr04672j274470932-s2.0-84981489633WOS:000381442500015https://api.elsevier.com/content/abstract/scopus_id/84981489633