Ross O.AWu Y.-RLee M.-CFunayama MChen M.-LSoto A.IMata I.FLee-Chen G.-JChiung M.CTang MZhao YHattori NFarrer M.JTan E.-KRUEY-MEEI WU2020-02-252020-02-2520080364-5134https://scholars.lib.ntu.edu.tw/handle/123456789/463715Common genetic variants that increase the risk for Parkinson's disease may differentiate patient subgroups and influence future individualized therapeutic strategies. Herein we show evidence for leucine-rich repeat kinase 2 (LRRK2) c.4883G>C (R1628P) as a risk factor in ethnic Chinese populations. A study of 1,986 individuals from 3 independent centers in Taiwan and Singapore demonstrates that Lrrk2 R1628P increases risk for Parkinson's disease (odds ratio, 1.84; 95% confidence interval, 1.20-2.83; p = 0.006). Haplotype analysis suggests an ancestral founder for carriers approximately 2,500 years ago. These findings support the importance of LKRK2 variants in sporadic Parkinson's disease. ? 2008 American Neurological Association. Published by Wiley-Liss, Inc., through Wiley Subscription Services.[SDGs]SDG3leucine rich repeat kinase 2; adult; article; Chinese; controlled study; genetic risk; genetic variability; haplotype; human; major clinical study; Parkinson disease; priority journal; risk factor; Singapore; Taiwan; Asian Continental Ancestry Group; DNA Mutational Analysis; Female; Founder Effect; Gene Frequency; Genetic Markers; Genetic Predisposition to Disease; Genetic Screening; Genotype; Humans; Male; Middle Aged; Mutation; Parkinson Disease; Polymorphism, Genetic; Protein-Serine-Threonine Kinases; Singapore; Taiwanjournal article10.1002/ana.21405184122652-s2.0-48949092066