Lin I.-C.Wang Y.-H.Wang T.-J.I-JONG WANGShen Y.-D.Chi N.-F.Chien L.-N.2021-07-012021-07-0120141932-6203https://www.scopus.com/inward/record.uri?eid=2-s2.0-84907569707&doi=10.1371%2fjournal.pone.0108938&partnerID=40&md5=f990a4c8ced9162c03d9b70e9a2ad6achttps://scholars.lib.ntu.edu.tw/handle/123456789/567260Background: Glaucoma is the leading cause of irreversible blindness worldwide and primary open-angle glaucoma (POAG) is the most common type of glaucoma. An association between POAG and the subsequent risk of Alzheimer's disease (AD) and Parkinson's disease (PD) was unclear.Objective: To investigate the association between POAG (including normal-tension glaucoma) and the subsequent risk of AD or PD 8 years following a diagnosis of POAG.Methods: We performed a retrospective, propensity-score-matched analysis of a population-based cohort consisting of patients with and without POAG aged 60 years and older. Control patients without POAG were propensity-score matched to POAG patients based on their baseline characteristics.Results: The incidence rates and confidence intervals (CIs) of AD among the patients with and without POAG were 2.85 (95% CI: 2.19-3.70) and 1.98 (95% CI: 1.68-2.31) per 1000 person-years, respectively. The incidence rates of PD among the POAG and non-POAG cohorts were 4.36 (95% CI: 3.52-5.39) and 4.37 (95% CI: 3.92-4.86) per 1000 person-years, respectively. Kaplan-Meier failure curves showed that the POAG patients had a higher risk of AD than the control patients did (log-rank test, P=.0189). However, the cumulative PD hazard ratios for the POAG and non-POAG patients did not differ significantly (log-rank test, P = .9953).Conclusion: In elderly patients, POAG is a significant predictor of AD, but POAG is not a predictor of PD. ? 2014 Lin et al.[SDGs]SDG3adult; age distribution; aged; Alzheimer disease; Article; cohort analysis; controlled study; disease association; disease duration; female; follow up; glaucoma; high risk population; human; incidence; major clinical study; male; middle aged; outcome assessment; Parkinson disease; patient assessment; retrospective study; risk assessment; risk factor; scoring system; Alzheimer disease; comorbidity; complication; demography; Glaucoma, Open-Angle; Kaplan Meier method; Parkinson disease; Taiwan; very elderly; Aged; Aged, 80 and over; Alzheimer Disease; Cohort Studies; Comorbidity; Demography; Female; Follow-Up Studies; Glaucoma, Open-Angle; Humans; Incidence; Kaplan-Meier Estimate; Male; Middle Aged; Parkinson Disease; Taiwanjournal article10.1371/journal.pone.0108938252755302-s2.0-84907569707