LI-FANG WANG2019-07-112019-07-111994-050300-9475https://scholars.lib.ntu.edu.tw/handle/123456789/413358(NZB x NZW)F1 (B/W) mice spontaneously develop a disease which is remarkably similar to systemic lupus erythematosus (SLE) in humans. This disease is characterized by the appearance of autoantibodies to double-stranded (ds)DNA and the subsequent development of fatal glomerulonephritis. The prophylactic treatment of B/W mice with syngeneic photomodulated autoimmune spleen cells was found to significantly improve survival, and to inhibit the outgrowth of autoreactive B cells and the production of high-titre IgG anti-dsDNA antibodies. The function of the autoreactive T cells in vivo, however, did not change significantly. Our findings suggested a novel treatment for spontaneously occurring autoantibody-related autoimmune diseases.en[SDGs]SDG3autoantibody; dna antibody; immunoglobulin g; interleukin 2; animal experiment; article; autoimmunity; b lymphocyte; enzyme linked immunosorbent assay; female; immunization; mouse; nonhuman; photoreactivity; spleen cell; systemic lupus erythematosus; t lymphocyte; Animal; Antibodies, Antinuclear; Autoimmune Diseases; B-Lymphocytes; Enzyme-Linked Immunosorbent Assay; Female; Mice; Mice, Inbred NZB; Mice, Inbred Strains; Photopheresis; Spleen; Support, Non-U.S. Gov'tjournal article10.1111/j.1365-3083.1994.tb03399.x81912202-s2.0-0028338925https://api.elsevier.com/content/abstract/scopus_id/0028338925