陳劉旺2006-07-252018-06-282006-07-252018-06-282000http://ntur.lib.ntu.edu.tw//handle/246246/9272因聚乙烯醇具有生物不活潑性質，且 由之前的研究證實了聚乙烯醇薄膜適用於 人工胰臟。本計畫進一步將聚乙烯醇薄膜 應用於人工胰臟的動物實驗，可觀察出在 植入M-2 管子之後，糖尿病老鼠的血糖濃 度從500±35 降到210±22 mg/dl ，經由植入 三組M-2 管子之後，更可以降到130-160 mg/dl 且可維持一個月。最後利用數學動力模型來解釋之。Our previous in vitro studies have demonstrated that poly (vinyl alcohol) (PVA) membranes satisfy the basic requirements for a bioartificial pancreas. This experiment was designed to evaluate the performance of m-1 and m-2 tubular membrane chambers containing islets in vivo. When the m-2 chamber was implanted into streptozotocin (STZ)-induced diabetic rats, nonfasting blood glucose levels dropped from 500±35 to the lowest value 210±22 mg/dl. Furthermore, the performance of the bioartificial pancreas can be enhanced by the increased numbers of implanted chambers. If three m-2 chambers was implanted, nonfasting blood glucose levels in the diabetic rats decreased to 130-160 mg/dl and such a low blood glucose value was maintained for 1 month. In addition, a mathematical kinetic model was developed to describe the characteristics of islet inside an artificial environment.application/pdf55689 bytesapplication/pdfzh-TW國立臺灣大學化學工程學系暨研究所人工胰臟糖尿病bioartificial pancreasdiabetes[SDGs]SDG3reporthttp://ntur.lib.ntu.edu.tw/bitstream/246246/9272/1/892216E002005.pdf