Shen Y.-C.Wang L.-T.Wang C.-H.Khalil A.T.JIH-HWA GUH2021-06-022021-06-02200492363https://www.scopus.com/inward/record.uri?eid=2-s2.0-3543147688&doi=10.1248%2fcpb.52.108&partnerID=40&md5=3917894dcc53aca53ae2e422bbd31a0ehttps://scholars.lib.ntu.edu.tw/handle/123456789/564877In addition to casearlucin A (3), two new clerodane diterpenes, caseamembrols A (1) and B (2) have been isolated from the leaves and twigs of Casearia membranacea by bioassay-guided fractionation. The structures of the new compounds were established on the basis of extensive 1D- and 2D-NMR spectroscopic analysis. Compounds 1-3 exhibited significant cytotoxicity against human prostate (PC-3) cancer cells. ? 2004 Pharmaceutical Society of Japan.Casearia membranacea; Clerodanes; Cytotoxicity; Flacourtiaceae[SDGs]SDG3caseamembrol a; caseamembrol b; casearlucin a; clerodane derivative; diterpene; plant extract; unclassified drug; alcohol; antineoplastic agent; caseamembrol A; caseamembrol B; clerodane derivative; diterpene; solvent; antineoplastic activity; article; bioassay; cancer cell; Casearia; Casearia membranacea; controlled study; cytotoxicity; drug isolation; drug structure; fractionation; human; human cell; nonhuman; nuclear magnetic resonance spectroscopy; plant leaf; prostate cancer; structure analysis; Casearia; chemistry; conformation; fast atom bombardment mass spectrometry; isolation and purification; male; pathology; plant stem; prostate tumor; thin layer chromatography; tumor cell line; ultraviolet spectrophotometry; Antineoplastic Agents, Phytogenic; Casearia; Cell Line, Tumor; Chromatography, Thin Layer; Diterpenes; Diterpenes, Clerodane; Ethanol; Humans; Magnetic Resonance Spectroscopy; Male; Molecular Conformation; Plant Leaves; Plant Stems; Prostatic Neoplasms; Solvents; Spectrometry, Mass, Fast Atom Bombardment; Spectrophotometry, Ultravioletjournal article10.1248/cpb.52.108147098762-s2.0-3543147688