SHENG-NAN CHANGJYH-MING JIMMY JUANGCHIA-TI TSAIKo J.-T.Lien W.-P.2020-12-282020-12-2820151932-6203https://www.scopus.com/inward/record.uri?eid=2-s2.0-84953269501&doi=10.1371%2fjournal.pone.0142175&partnerID=40&md5=a6953223b34b883281cc8212df2a3b7chttps://scholars.lib.ntu.edu.tw/handle/123456789/533964Background We propose a novel integrated score index, which could be used to quantify and grade left ventricular (LV) diastolic function. Methods We enrolled 629 participants [393 healthy subjects, 145 with hypertension (HTN), 24 with hypertrophic cardiomyopathy (HCM), and 67 with coronary artery disease (CAD)]. This score index was with a score of 1 for an E/A ratio < 1, a score of 1 for a septal e'/a' ratio ? 0.8, a score of 2 for a lateral e'/a' ratio ? 1, a score of 2 for a septal E/e' ratio ?10-15, a score of 3 for a lateral E/e' ratio ? 8-15, and a score of 1 for a deceleration time >240 ms. The sum of each score was considered as the final value in this scoring method (either a septal or a lateral E/e' ratio > 15 was given a total score of 10, regardless of the other measurements). Results After analysis, the AUROC of this integrated score index for predicting any diastolic dysfunction (discriminated by the American Society of Echocardiography guidelines) was 0.962, and the AUROC of the method from the logistic regression was 0.970. The mean values of the score index for the groups were 3.81 ± 0.12 in healthy, 6.48 ± 0.19 in HTN, 7.35 ± 0.46 in HCM, and 6.62 ± 0.29 in CAD. Using the score index, the healthy subjects obtained lower scores compared with those of HTN (p = 0.00), HCM (p = 0.00), and CAD (p = 0.00). Therefore, this score index could discriminate patients with diseases with impaired diastolic function from the healthy subjects when the total sum of the score was equal to or greater than 4. Conclusions If the presently used methods cannot allow the clear diagnosis of LV diastolic dysfunction, this integrated score index might be helpful for discriminating diseases with impaired diastolic function. ? 2015 Chang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.[SDGs]SDG3[SDGs]SDG10Article; cardiovascular disease assessment; cardiovascular risk; controlled study; coronary artery disease; diagnostic accuracy; diagnostic test accuracy study; diagnostic value; Doppler echocardiography; female; heart failure; human; hypertension; hypertrophic cardiomyopathy; integrated score index; left ventricular diastolic dysfunction; major clinical study; male; predictive value; pressure gradient; receiver operating characteristic; risk assessment; scoring system; systolic blood pressure; transthoracic echocardiography; case control study; diagnostic imaging; diastole; heart left ventricle function; pathophysiology; pulsed Doppler echocardiography; Cardiomyopathy, Hypertrophic; Case-Control Studies; Diastole; Echocardiography, Doppler, Pulsed; Female; Humans; Hypertension; Male; Ventricular Function, Leftjournal article10.1371/journal.pone.0142175265555982-s2.0-84953269501