YEN-HUNG LINLIAN-YU LINChen, Ying-ShrenYing-ShrenChenHUI-CHUN HUANGJEN-KUANG LEEYI-LWUN HOLiao, Lin-ChuLin-ChuLiaoWEN-JONE CHEN2022-02-272022-02-272009-0901478389https://scholars.lib.ntu.edu.tw/handle/123456789/595810Background: Whether T-wave morphology descriptors on the 12-lead electrocardiogram (ECG) can predict the occurrence of life-threatening ventricular arrhythmia in patients with advanced congestive heart failure is unclear. Methods: Standard 12-lead ECGs were photoscanned and digitized for analysis in 27 heart failure patients with ventricular tachycardia/ventricular fibrillation (VT/VF; study group), as well as in 54 age- and sex-matched heart failure patients without life-threatening ventricular arrhythmia as a control group. Novel T-wave morphology descriptors were compared. Results: The results showed that the temporal descriptor, the lead dispersion (LD; 426.5 +/- 279.8 vs 189.0 +/- 125.7, P < 0.001), was significantly higher in the study than in the control group. The other T-wave morphology parameters, such as the T-wave morphology dispersion (45.7 +/- 20.1 vs 44.9 +/- 18.6), the total cosine between QRS and T wave (TCRT; -0.4 +/- 0.4 vs -0.5 +/- 0.3), and the normalized T-loop area (NTLA; 0.5 +/- 0.1 vs 0.4 +/- 0.1), were not significantly different between the two groups (all P value > 0.05). After an adjustment for other clinical variables, increased LD (odds ratio: 9.9, 95% confidence interval [CI]: 2.9-33.4, P < 0.001) or decreased NTLA (odds ratio: 0.4, 95% CI: 0.1-1.0, P =0.05) was associated with VT/VF. Conclusion: The novel T-wave morphology analysis may help in identifying heart failure patients at high risk for VT/VF.enCongestive heart failure; Sudden cardiac death; T-wave morphology; Ventricular repolarization[SDGs]SDG3journal article10.1111/j.1540-8159.2009.02461.x197194952-s2.0-69849102691