曾慶孝2006-07-262018-07-112006-07-262018-07-112004http://ntur.lib.ntu.edu.tw//handle/246246/23666本研究以宜蘭縣曾由飲用水中暴露於 無機砷的居民為對象，探討glutathione S-transferase (GST) T1 基因型與糖尿病的 可能相關性。總計完成651 位受檢者的GST T1 基因型分析，其中78 位患有糖尿病， 另外573 位為無糖尿病之對照組。GST T1 基因型以聚合脢鏈鎖反應方式進行，且分 為null type 及non-null type 二型。結果顯 示在年齡、性別及身體質量指數匹配之情 況下，對照組之null type 盛行率為 58.3%，而糖尿病組則為46.2% (p<0.05),顯 示GSTT1 non-null type 與糖尿病的發生有 關。未來我們須要更大樣本之進一步分 析，並針對砷代謝產物及解毒過程對疾病 的發生相關性研究，將有助於進一步釐清砷引起之健康危害的影響。This study evaluated the possible association between diabetes mellitus and the glutathione S-transferase (GST) T1 genotype in residents of the Ilan county, who showed history of arsenic exposure from drinking well water. A total of 651 subjects were studied. Among them, 76 were diabetic and 573 were not diabetic. GST T1 genotyping was performed by a polymerase chain reaction technique and the genotypes were classified as null and non-null types. Results showed that with comparable age, sex and body mass index, GST T1 null type was present in 58.3% of the non-diabetic subjects and 46.2% of the diabetic patients (p<0.05), suggesting an association between non-null type GSTT1 and diabetes mellitus. Further studies with larger sample size or studies involving the metabolites of arsenic and the detoxification procedures are required to clarify the role of arsenic on the impact of human health hazards.application/pdf78969 bytesapplication/pdfzh-TW國立臺灣大學醫學院內科糖尿病環境污染物砷聚合脢鏈鎖反應分子生物學diabetes mellitusenvironmental pollutantsarsenicpolymerase chain reactionmolecular biology[SDGs]SDG3reporthttp://ntur.lib.ntu.edu.tw/bitstream/246246/23666/1/922320B002156.pdf