2011-01-012024-05-13https://scholars.lib.ntu.edu.tw/handle/123456789/646235摘要：藥物濫用在全世界都是越來越嚴重，聯合國整合全球社會再次承諾未來十年對付世界藥物濫用問題。最近藥物濫用除了以往所認知的黑市藥物（如海洛因、安非他命、搖頭丸等）外，近年來處方藥（如安眠鎮靜劑、成癮性止痛藥等）濫用問題日益嚴重。美國處方藥物的濫用比海洛因、安非他命、或古柯鹼的濫用更為普遍。男性和女性在生理特徵、社會地位、經濟能力、和政治權力等面向，都有很大的差異。物質濫用是一種和生理、心理、社會、經濟和政治權力等各方面均相關之「疾病」。因此男女性別上之差異，值得從各角度去探討其意義。美國研究報導指出，女性比男性更易於濫用處方藥，特別是麻醉止痛藥和抗焦慮劑等藥物。台灣藥物濫用者以往均以男性為主，但近年來對本國青少年之問卷調查發現，女性和男性之吸毒發生率相當。但查詢目前發表之文獻，台灣對處方藥濫用並未有很多之研究。目前對台灣藥物濫用之性別差異之資料似乎不足，尤其對本國女性在處方藥物濫用是不是如同國外之報告，比男性更易成癮，目前並無充足之證據。本計畫為研究藥物濫用之性別差異及本國處方藥濫用之流行病學研究，彙整、比較及研析國內外藥物濫用性別差異之流行病學相關研究文獻及處方藥濫用對男女主體健康危害之影響評估，以作為藥物濫用防制政策之重要參考。本計畫進行方式為收集國內外之研究論文，以彙整、比較及研析國內外藥物濫用流行病學上之性別差異。另一方面利用健保局之健保百萬歸人抽樣資料檔案，嘗試以不同搜尋方式，尋找出可能為成癮性止痛藥品及鎮靜安眠藥物二類處方藥之濫用病人。希望本研究結果與所收集到之國內外藥物濫用流行病學相關研究文獻，可以對本國男女主體健康危害之影響評估，以作為藥物濫用防制政策之重要參考。<br> Abstract: Drug abuse is a growing concern in the world. United Nations endeavors, in cooperation with Governments, to ensure that the diversion of drugs from licit sources to illicit channels does not occur. Recently, the behavior of drug abuse shifts from “street drugs” (such as, heroin, amphetamine, ecstasy, etc.) to prescription drugs (such as, psychotherapeutic drugs and narcotics). Recent reports demonstrated that prescription drug abuse exceeded street drugs in the United States and Canada.Men and women are different in physical, social, economic, political status. Drug abuse is a disease involved in physical, social, economic, political aspects. Therefore, the gender differences in drug abuse are worthy to research in many aspects. Women are more likely to use prescription drugs non-medically than men in the United States, especially to use psychotherapeutics and narcotics. Drug abusers are usually predominant in men in Taiwan. However, recent study showed that the prevalence of drug abuse is equally between male or female teenagers in Taiwan. The data about prescription drug abuse, however, are still scanty.Currently, we did not find enough data about the prevalence of drug abuse to identify the gender difference in this situation in Taiwan. Especially, there were no data about the epidemiology of prescription drug abuse in our country. Therefore, we would like to examine the followings in this project. First, we will do an extensive literature review to comparing the reports in the world about the gender differences in drug abuse. These differences may lead to format a special prevention project in drug abuse. Second, we will use the database of National Health Insurance to identify the patients abusing sedatives and narcotics. Try to analyze the epidemic characteristics of these patients, including gender differences, preferring drugs, frequency and dosage of sedatives and narcotics. The comorbidity of these patients could also be evaluated. We can also evaluate the prevalence rate of prescription drug abuse in Taiwan. Combining the literature review and our own data, we may make some suggestions about the prevention and treatment of prescription drug abuse in Taiwan.性別差異藥物濫用處方藥物濫用流行病學Gender differencedrug abuseprescription drug abuseepidemiology