CHIEN-HSIEH CHIANGKUO-CHIN HUANG2021-01-142021-01-1420141007-9327https://www.scopus.com/inward/record.uri?eid=2-s2.0-84902663011&doi=10.3748%2fwjg.v20.i23.7213&partnerID=40&md5=d47bb93cf68910ba802eca808a965da0https://scholars.lib.ntu.edu.tw/handle/123456789/540679There are limited data regarding the relationship between chronic hepatitis B virus (HBV) infection and metabolic factors. This article aims to highlight the link of metabolic factors with hepatitis B surface antigen (HBsAg) serostatus, HBV load, and HBV-related hepatocellular carcinoma (HCC). Although HBsAg-positive serostatus was positively correlated with a high risk of metabolic syndrome in students, chronic HBV-infected individuals have high serum adiponectin levels. The androgen pathway in HBV carriers with a low body mass index is more triggered which leads to enhanced HBV replication. High HBV load was inversely associated with obesity in hepatitis B e antigen (HBeAg)-seropositive HBV carriers; while in HBeAg-seronegative HBV carriers, high HBV load was inversely related to hypertriglyceridemia rather than obesity. For overweight and obese HBV-infected patients, high HBV load was positively associated with serum adiponectin levels. Several large cohort studies have revealed a positive link of diabetes with incidence of HBV-related HCC. However, the association between incidence of HCC and metabolic factors other than diabetes is still inconclusive. More long-term prospective studies should elucidate the association of chronic HBV infection and its outcomes with metabolic factors in clinical practice. ? 2014 Baishideng Publishing Group Inc. All rights reserved.[SDGs]SDG3adiponectin; hepatitis B surface antigen; hepatitis B(e) antigen; hydroxymethylglutaryl coenzyme A reductase inhibitor; peroxisome proliferator activated receptor gamma; protein X; adiponectin; ADIPOQ protein, human; biological marker; hepatitis B surface antigen; article; body mass; cancer incidence; cholesterol blood level; clinical trial (topic); diabetes mellitus; disease association; gene expression; hepatitis B; Hepatitis B virus; human; hypertriglyceridemia; liver biopsy; liver cell carcinoma; liver function; metabolic syndrome X; metabolism; nonhuman; obesity; risk factor; serology; steatosis; virus load; virus replication; animal; blood; complication; diabetes mellitus; Dyslipidemias; Hepatitis B, Chronic; immunology; liver tumor; metabolism; obesity; pathogenicity; virology; Adiponectin; Animals; Biological Markers; Carcinoma, Hepatocellular; Diabetes Mellitus; Dyslipidemias; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Neoplasms; Obesity; Risk Factors; Viral Load; Virus Replicationjournal article10.3748/wjg.v20.i23.7213249665912-s2.0-84902663011