Wang C.‐C.HWEI-FANG TIENLin M.‐T.Su I.‐J.Wang C.‐H.Chuang S.‐M.MING-CHING SHENLiu C.‐H.2021-01-042021-01-0419951045-2257https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028945858&doi=10.1002%2fgcc.2870120302&partnerID=40&md5=5ac61be3807dd66f3a30111a79110c9ahttps://scholars.lib.ntu.edu.tw/handle/123456789/537571Peripheral T?cell lymphoma (PTL), which is characterized by hepatosplenic presentation and the γ/δ T?cell receptor (TCR) phenotype on the malignant cells, is a rare but distinct subtype of non?Hodgkin's lymphomas. Little is known about the chromosomal changes in these lymphomas. We report the cytogenetic analysis of three patients who had neoplastic proliferation of T γ/δ cells in the spleen, bone marrow, and liver, but not in lymph nodes or skin. Isochromosome 7q and trisomy 8 were observed in all three patients. Isochromosome 7q as the sole abnormality has been previously reported in one patient with similar clinicopathologic features. It is suggested that i(7q) is a primary, nonrandom chromosomal abnormality in hepatosplenic T γ/δ PTL. Copyright ? 1995 Wiley?Liss, Inc., A Wiley Company[SDGs]SDG3t lymphocyte receptor; adult; article; cancer genetics; case report; chromosome 7q; chromosome analysis; clinical examination; human; isochromosome; liver tumor; male; priority journal; spleen tumor; t cell lymphoma; trisomy 8; Adult; Antigens, CD; Bone Marrow; Case Report; Chromosomes, Human, Pair 7; Chromosomes, Human, Pair 8; Fatal Outcome; Genetic Markers; Human; Isochromosomes; Liver Neoplasms; Lymphoma, T-Cell, Peripheral; Male; Receptors, Antigen, T-Cell, gamma-delta; Spleen; Splenic Neoplasms; Support, Non-U.S. Gov't; Trisomyjournal article10.1002/gcc.287012030275364542-s2.0-0028945858